<p>The half-life of meloxicam is approximately 20 hours<sup class="text-reference-group"><a class="reference-popover-link" data-content="Turck D, Roth W, Busch U: A review of the clinical pharmacokinetics of meloxicam. Br J Rheumatol. 1996 Apr;35 Suppl 1:13-6. doi: 10.1093/rheumatology/35.suppl_1.13. (PubMed ID 8630630)" href="#reference-A190195">3</a></sup>, which is considerably longer than most other NSAIDS. It can therefore be dosed without the need for slow-release formulations.<sup class="text-reference-group"><a class="reference-popover-link" data-content="Bekker A, Kloepping C, Collingwood S: Meloxicam in the management of post-operative pain: Narrative review. J Anaesthesiol Clin Pharmacol. 2018 Oct-Dec;34(4):450-457. doi: 10.4103/joacp.JOACP_133_18. (PubMed ID 30774225)" href="#reference-A190189">1</a></sup></p><p>Meloxicam applied together with <a href="https://go.drugbank.com/drugs/DB00297">bupivacaine</a> for postsurgical analgesia had a median half-life of 33-42 hours, depending on dose and application site.<sup class="text-reference-group"><a class="reference-popover-link" data-content="FDA Approved Drug Products: ZYNRELEF (bupivacaine and meloxicam) extended-release solution for injection" href="#reference-L34100">13</a></sup></p>