<p>Hydrocortisone, or cortisol, is a glucocorticoid secreted by the adrenal cortex.<sup class="text-reference-group"><a class="reference-popover-link" data-content="Jung C, Greco S, Nguyen HH, Ho JT, Lewis JG, Torpy DJ, Inder WJ: Plasma, salivary and urinary cortisol levels following physiological and stress doses of hydrocortisone in normal volunteers. BMC Endocr Disord. 2014 Nov 26;14:91. doi: 10.1186/1472-6823-14-91. (PubMed ID 25425285)" href="#reference-A188387">7</a></sup> Hydrocortisone is used to treat immune, inflammatory, and neoplastic conditions.<sup class="text-reference-group"><a class="reference-popover-link" data-content="FDA Approved Drug Products: Vosol Hydrocortisone and Glacial Acetic Acid Otic Drops" href="#reference-L10529">14</a>,<a class="reference-popover-link" data-content="FDA Approved Drug Products: Casporyn Neomycin Sulfate, Polymixin B Sulfate, and Hydrocortisone Otic Drops" href="#reference-L10532">15</a>,<a class="reference-popover-link" data-content="FDA Approved Drug Products: Cortef Hydrocortisone Oral Tablets" href="#reference-L10535">16</a>,<a class="reference-popover-link" data-content="FDA Approved Drug Products: Cortenema Hydrocortisone Rectal Enema" href="#reference-L10538">17</a>,<a class="reference-popover-link" data-content="FDA Approved Drug Products: Bacitracin, Neomycin, Polymyxin B, and Hydrocortisone Topical Ointment" href="#reference-L7772">18</a>,<a class="reference-popover-link" data-content="FDA Approved Drug Products: Xerese (Acyclovir and Hydrocortisone) Topical Cream" href="#reference-L7321">19</a></sup> It was discovered in the 1930s by Edward Kendall and named Compound F, or 17-hydroxycorticosterone.<sup class="text-reference-group"><a class="reference-popover-link" data-content="Simoni R, Hill R, Vaughan M: The Isolation of Thyroxine and Cortisone: the Work of Edward C. Kendall Journal of Biological Chemistry. 2002 May 24;277(21):e10." href="#reference-A188420">9</a></sup></p><p>Hydrocortisone was granted FDA approval on 5 August 1952.<sup class="text-reference-group"><a class="reference-popover-link" data-content="FDA Approved Drug Products: Hydrocortone Hydrocortisone Oral Tablets (Discontinued)" href="#reference-L10574">20</a></sup></p>