<p>Emtricitabine is approximately 86% unmetabolized.<sup class="text-reference-group"><a class="reference-popover-link" data-content="FDA Approved Drug Products: Emtriva (Emtricitabine) Oral Capsules" href="#reference-L9019">6</a></sup> Approximately 9% of a dose is metabolized to 3'-sulfoxide diastereomers, 4% to the 2'-O-glucuronide, and a minor amount is converted to 5-fluorocytosine.<sup class="text-reference-group"><a class="reference-popover-link" data-content="Shockcor JP, Wurm RM, Frick LW, Sanderson PN, Farrant RD, Sweatman BC, Lindon JC: Hplc-nmr identification of the human urinary metabolites of (-)-cis-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl] cytosine, a nucleoside analogue active against human immunodeficiency virus (HIV). Xenobiotica. 1996 Feb;26(2):189-99. doi: 10.3109/00498259609046699. (PubMed ID 8868002)" href="#reference-A187643">1</a>,<a class="reference-popover-link" data-content="FDA Approved Drug Products: Emtriva (Emtricitabine) Oral Capsules" href="#reference-L9019">6</a></sup></p><p class="d-none d-sm-block"><strong>Hover over products below to view reaction partners</strong></p>