Interacting Gene/EnzymeAllele nameGenotype(s)Defining Change(s)Type(s)DescriptionDetailsHeat shock 70 kDa protein 1-like---(T;T) / (C;T)T alleleADR Directly StudiedPatients with this genotype have increased risk of cutaneous hypersensitivity reactions with carbamazepine.DetailsHeat shock 70 kDa protein 1A/1B---(C;G) / (C;C) / (C;T)C allele / C alleleADR Directly StudiedPatients with this genotype have increased risk of cutaneous hypersensitivity reactions with carbamazepine.DetailsHLA class I histocompatibility antigen, B-15 alpha chain---(T;T) / (G;T)T alleleADR Directly StudiedPatients with this genotype have increased risk of cutaneous hypersensitivity reactions with carbamazepine.DetailsHLA class I histocompatibility antigen, A-31 alpha chain---(G;G) / (C;G)G alleleADR Directly StudiedPatients with this genotype have increased risk of cutaneous hypersensitivity reactions with carbamazepine.DetailsPromotilin---(A;A) / (A;C)A alleleADR Directly StudiedPatients with this genotype have increased risk of cutaneous hypersensitivity reactions with carbamazepine.DetailsSodium channel protein type 1 subunit alpha---(A;A) / (A;G)IVS5N + 5 G>AEffect Directly StudiedPatients with this genotype have increased resistance to the anti-epileptic effects of carbamazepine.DetailsFlotillin-1HLA-B*1502(G;G) / (C;G)G > C / G > CADR Directly StudiedTaiwanese, Chinese, Indians, and Chinese–American patients with this genotype have increased risk of Stevens-Johnson syndrome or toxic epidermal necrolysis with carbamazepine.DetailsMucin-21HLA-B*1502(G;G) / (A;G)G>A / G>AADR Directly StudiedTaiwanese, Chinese, Indians, and Chinese–American patients with this genotype have increased risk of Stevens-Johnson syndrome or toxic epidermal necrolysis with carbamazepine.DetailsHLA class I histocompatibility antigen, B-15 alpha chainHLA-B*15:02Not AvailableHLA-B*15ADR Directly StudiedPatients who carry this allele may be at an increased risk of Stevens-Johnson Syndrome and toxic epidermal necrolysis when treated with carbamazepine.DetailsHLA class I histocompatibility antigen, A-3 alpha chainHLA-A*3101(T;T) / (A;T)A > TADR Directly StudiedPatients who carry this genotype in HLA-A are at a higher risk of experiencing a hypersensitivity reaction to carbamazepine.Details