<p><strong>Apparent clearance</strong></p><p>1367 ± 348 (50mg of progesterone administered by vaginal insert once daily) <sup class="text-reference-group"><a class="reference-popover-link" data-content="Paulson RJ, Collins MG, Yankov VI: Progesterone pharmacokinetics and pharmacodynamics with 3 dosages and 2 regimens of an effervescent micronized progesterone vaginal insert. J Clin Endocrinol Metab. 2014 Nov;99(11):4241-9. doi: 10.1210/jc.2013-3937. Epub 2014 Feb 25. (PubMed ID 24606090)" href="#reference-A175657">11</a></sup>.</p><p>106 ± 15 L/h (50mg/mL IM injection once daily) <sup class="text-reference-group"><a class="reference-popover-link" data-content="Paulson RJ, Collins MG, Yankov VI: Progesterone pharmacokinetics and pharmacodynamics with 3 dosages and 2 regimens of an effervescent micronized progesterone vaginal insert. J Clin Endocrinol Metab. 2014 Nov;99(11):4241-9. doi: 10.1210/jc.2013-3937. Epub 2014 Feb 25. (PubMed ID 24606090)" href="#reference-A175657">11</a></sup>.</p>