<p>The LD50 of oral amiodarone in mice and rats exceeds 3,000 mg/kg.<sup class="text-reference-group"><a class="reference-popover-link" data-content="FDA Approved Drug Products: CORDARONE (amiodarone HCl) tablets" href="#reference-L3561">18</a></sup>
An overdose with amiodarone can have a fatal outcome due to its potential to cause arrhythmia. Signs or symptoms of an overdose may include, hypotension, shock, bradycardia, AV block, and liver toxicity. In cases of an overdose, initiate supportive treatment and, if needed, use fluids, vasopressors, or positive inotropic agents. Temporary pacing may be required for heart block. Ensure to monitor liver function regularly. Amiodarone and its main metabolite, DEA, are not removable by dialysis.<sup class="text-reference-group"><a class="reference-popover-link" data-content="Nexterone FDA label" href="#reference-L8087">17</a></sup></p>