<p>Most drug is metabolized to glucuronide conjugates (30-50%) of the parent drug or of metabolites.<sup class="text-reference-group"><a class="reference-popover-link" data-content="Official drug label" href="#label-reference">Label</a>,<a class="reference-popover-link" data-content="Zaccara G, Messori A, Moroni F: Clinical pharmacokinetics of valproic acid--1988. Clin Pharmacokinet. 1988 Dec;15(6):367-89. doi: 10.2165/00003088-198815060-00002. (PubMed ID 3149565)" href="#reference-A178066">27</a></sup> Another large portion is metabolized through mitochondrial β-oxidation (40%). The remainder of metabolism (15-20%) occurs through oxidation, hydroxylation, and dehydrogenation at the ω, ω<sub>1</sub>, and ω<sub>2</sub> positions resulting in the formation of hydroxyls, ketones, carboxyls, a lactone metabolite, double bonds, and combinations. </p><p class="d-none d-sm-block"><strong>Hover over products below to view reaction partners</strong></p>