<p>The intraperitoneal LD<sub>50</sub> in rats is 2g/kg and 65mg/kg in mice.<sup class="text-reference-group"><a class="reference-popover-link" data-content="Cayman Chemicals: Prednisolone MSDS" href="#reference-L9545">8</a></sup> The subcutaneous LD<sub>50</sub> in rats is 147mg/kg and &gt;3500mg/kg in mice.<sup class="text-reference-group"><a class="reference-popover-link" data-content="Cayman Chemicals: Prednisolone MSDS" href="#reference-L9545">8</a></sup> The oral LD<sub>50</sub> in mice is 1680mg/kg.<sup class="text-reference-group"><a class="reference-popover-link" data-content="Cayman Chemicals: Prednisolone MSDS" href="#reference-L9545">8</a></sup> In humans, the oral TDLO in men is 9mg/kg/2W and in women is 14mg/kg/13D.<sup class="text-reference-group"><a class="reference-popover-link" data-content="Cayman Chemicals: Prednisolone MSDS" href="#reference-L9545">8</a></sup></p><p>Patients experiencing an overdose of prednisolone may present with gastrointestinal disturbances, insomnia, and restlessness.<sup class="text-reference-group"><a class="reference-popover-link" data-content="Robinson J, McKenzie C, MacLeod D: Paediatric dosing errors with oral prednisolone mixture. Aust Prescr. 2016 Oct;39(5):176. doi: 10.18773/austprescr.2016.062. Epub 2016 Oct 1. (PubMed ID 27789930)" href="#reference-A187511">5</a></sup> Overdose of oral prednisolone may be treated by gastric lavage or inducing vomiting if the overdose was recent, as well as supportive and symptomatic therapy.<sup class="text-reference-group"><a class="reference-popover-link" data-content="FDA Approved Drug Products: Prednisolone Acetate Oral Suspension" href="#reference-L9449">9</a></sup> Chronic overdosage may be treated by dose reduction or treating patients on alternate days.<sup class="text-reference-group"><a class="reference-popover-link" data-content="FDA Approved Drug Products: Prednisolone Acetate Oral Suspension" href="#reference-L9449">9</a></sup> An overdose by the ophthalmic route is not expected to cause problems.<sup class="text-reference-group"><a class="reference-popover-link" data-content="FDA Approved Drug Products: Prednisolone Acetate Oral Suspension" href="#reference-L9449">9</a></sup></p>