<p>The oral TDLO in mice is 1000mg/kg and in rats is 2000mg/kg.<sup class="text-reference-group"><a class="reference-popover-link" data-content="FDA Approved Drug Products: Losartan Oral Tablets" href="#reference-L7423">3</a>,<a class="reference-popover-link" data-content="FDA Approved Drug Products: Losartan and Hydrochlorothiazide Oral Tablets" href="#reference-L7426">4</a></sup> In humans the TDLO for men is 10mg/kg/2W and for women is 1mg/kg/1D.<sup class="text-reference-group"><a class="reference-popover-link" data-content="Cayman Chemicals: Losartan Potassium MSDS" href="#reference-L7441">5</a></sup></p><p>Symptoms of overdose are likely to include hypotension, tachycardia, or bradycardia due to vagal stimulation.<sup class="text-reference-group"><a class="reference-popover-link" data-content="FDA Approved Drug Products: Losartan Oral Tablets" href="#reference-L7423">3</a>,<a class="reference-popover-link" data-content="FDA Approved Drug Products: Losartan and Hydrochlorothiazide Oral Tablets" href="#reference-L7426">4</a></sup> Supportive treatment should be instituted for symptomatic hypotension.<sup class="text-reference-group"><a class="reference-popover-link" data-content="FDA Approved Drug Products: Losartan Oral Tablets" href="#reference-L7423">3</a>,<a class="reference-popover-link" data-content="FDA Approved Drug Products: Losartan and Hydrochlorothiazide Oral Tablets" href="#reference-L7426">4</a></sup> Hemodialysis will not remove losartan or its active metabolite due to their high rates of protein binding.<sup class="text-reference-group"><a class="reference-popover-link" data-content="FDA Approved Drug Products: Losartan Oral Tablets" href="#reference-L7423">3</a>,<a class="reference-popover-link" data-content="FDA Approved Drug Products: Losartan and Hydrochlorothiazide Oral Tablets" href="#reference-L7426">4</a></sup></p>