<p>The oral LD50 in rats is 98 mg/kg.<sup class="text-reference-group"><a class="reference-popover-link" data-content="Medsafe NZ: Mobictab (meloxicam) oral tablets" href="#reference-L11470">11</a></sup> Signs and symptoms of overdose with meloxicam may include shallow breathing, seizure, decreased urine output, gastrointestinal irritation, nausea, vomiting, gastrointestinal bleeding, and black tarry stools.<sup class="text-reference-group"><a class="reference-popover-link" data-content="American College of Cardiology: Meloxicam" href="#reference-L11473">12</a></sup> In the case of an overdose, offer supportive treatment and attempt to remove gastrointestinal contents. Cholestyramine has been shown to enhance the elimination of meloxicam.<sup class="text-reference-group"><a class="reference-popover-link" data-content="Medsafe NZ: Mobictab (meloxicam) oral tablets" href="#reference-L11470">11</a></sup></p>