<p>Celecoxib is indicated for symptomatic treatment of adult osteoarthritis (OA) and adult rheumatoid arthritis (RA).<sup class="text-reference-group"><a class="reference-popover-link" data-content="FDA Approved Drug Products: CELEBREX (celecoxib) oral capsules" href="#reference-L7646">31</a></sup> Celecoxib is not a substitute for aspirin for cardiovascular event prophylaxis.<sup class="text-reference-group"><a class="reference-popover-link" data-content="FDA Approved Drug Products: CELEBREX (celecoxib) oral capsules" href="#reference-L7646">31</a></sup> </p><p>It may be also be used to treat acute pain from various sources, juvenile rheumatoid arthritis in children over 2, ankylosing spondylitis, and primary dysmenorrhea.<sup class="text-reference-group"><a class="reference-popover-link" data-content="FDA Approved Drug Products: CELEBREX (celecoxib) oral capsules" href="#reference-L7646">31</a></sup></p><p>Celecoxib, in combination with <a href="https://go.drugbank.com/drugs/DB00193">tramadol</a>, is indicated for the management of acute pain in adults severe enough to require an opioid analgesic and in whom alternative treatments are inadequate.<sup class="text-reference-group"><a class="reference-popover-link" data-content="FDA Approved Drug Products: SEGLENTIS (celecoxib and tramadol hydrochloride) tablets" href="#reference-L38949">33</a></sup></p>