<p>Otic solutions are indicated for infections of the external auditory canal caused by susceptible organisms and with inflammation.<sup class="text-reference-group"><a class="reference-popover-link" data-content="FDA Approved Drug Products: Vosol Hydrocortisone and Glacial Acetic Acid Otic Drops" href="#reference-L10529">14</a>,<a class="reference-popover-link" data-content="FDA Approved Drug Products: Casporyn Neomycin Sulfate, Polymixin B Sulfate, and Hydrocortisone Otic Drops" href="#reference-L10532">15</a></sup> Hydrocortisone tablets are indicated for certain endocrine, rheumatic, collagen, allergic, ophthalmic, respiratory, hematologic, neoplastic, edematous, gastrointestinal, and other conditions.<sup class="text-reference-group"><a class="reference-popover-link" data-content="FDA Approved Drug Products: Cortef Hydrocortisone Oral Tablets" href="#reference-L10535">16</a></sup> A hydrocortisone enema is indicated for ulcerative colitis,<sup class="text-reference-group"><a class="reference-popover-link" data-content="FDA Approved Drug Products: Cortenema Hydrocortisone Rectal Enema" href="#reference-L10538">17</a></sup> a topical ointment with antibiotics is indicated for corticosteroid responsive dermatoses with infections,<sup class="text-reference-group"><a class="reference-popover-link" data-content="FDA Approved Drug Products: Bacitracin, Neomycin, Polymyxin B, and Hydrocortisone Topical Ointment" href="#reference-L7772">18</a></sup> and a topical cream with <a href="https://go.drugbank.com/drugs/DB00787">acyclovir</a> is indicated to treat cold sores.<sup class="text-reference-group"><a class="reference-popover-link" data-content="FDA Approved Drug Products: Xerese (Acyclovir and Hydrocortisone) Topical Cream" href="#reference-L7321">19</a></sup> Oral granules of hydrocortisone are used as a replacement therapy for Adrenocortical Insufficiency (AI) in children under 17 years of age.<sup class="text-reference-group"><a class="reference-popover-link" data-content="FDA Approved Drug Products: ALKINDI SPRINKLE (hydrocortisone) oral granules" href="#reference-L16533">21</a></sup></p>