<p>The elimination half-life of naproxen is reported to be 12-17 hours.<sup class="text-reference-group"><a class="reference-popover-link" data-content="Brutzkus JC, Varacallo M: Naproxen . (PubMed ID 30247840)" href="#reference-A178975">3</a></sup><sup class="text-reference-group"><a class="reference-popover-link" data-content="Naprosyn FDA Label" href="#reference-L6583">13</a></sup></p>