<p>The apparent volume of distribution of celecoxib at steady state (Vss/F) is about 429 L<sup class="text-reference-group"><a class="reference-popover-link" data-content="Pfizer Medical Information" href="#reference-L3296">25</a></sup>, which suggests wide distribution into various tissues. Celecoxib is not preferentially bound to red blood cells.<sup class="text-reference-group"><a class="reference-popover-link" data-content="FDA Approved Drug Products: CELEBREX (celecoxib) oral capsules" href="#reference-L7646">31</a></sup> Another resource reports a volume of distribution of 455 ± 166L.<sup class="text-reference-group"><a class="reference-popover-link" data-content="Ahmad SR, Kortepeter C, Brinker A, Chen M, Beitz J: Renal failure associated with the use of celecoxib and rofecoxib. Drug Saf. 2002;25(7):537-44. doi: 10.2165/00002018-200225070-00007. (PubMed ID 12093311)" href="#reference-A4983">12</a></sup></p>