<p>The volume of distribution ranged from 0.34 to 1.57 L/kg following oral, intravenous, or rectal administration of single and multiple doses of indometacin in healthy individuals.<sup class="text-reference-group"><a class="reference-popover-link" data-content="Alvan G, Orme M, Bertilsson L, Ekstrand R, Palmer L: Pharmacokinetics of indomethacin. Clin Pharmacol Ther. 1975 Sep;18(3):364-73. (PubMed ID 1100305)" href="#reference-A177964">7</a></sup> Indometacin is distributed into the synovial fluid <sup class="text-reference-group"><a class="reference-popover-link" data-content="Helleberg L: Clinical Pharmacokinetics of indomethacin. Clin Pharmacokinet. 1981 Jul-Aug;6(4):245-58. doi: 10.2165/00003088-198106040-00001. (PubMed ID 7249487)" href="#reference-A177874">2</a></sup> and is extensively bound to tissues <sup class="text-reference-group"><a class="reference-popover-link" data-content="Weber M, Kodjikian L, Kruse FE, Zagorski Z, Allaire CM: Efficacy and safety of indomethacin 0.1% eye drops compared with ketorolac 0.5% eye drops in the management of ocular inflammation after cataract surgery. Acta Ophthalmol. 2013 Feb;91(1):e15-21. doi: 10.1111/j.1755-3768.2012.02520.x. Epub 2012 Sep 12. (PubMed ID 22970738)" href="#reference-A177949">6</a></sup>. It has been detected in human breast milk <sup class="text-reference-group"><a class="reference-popover-link" data-content="Helleberg L: Clinical Pharmacokinetics of indomethacin. Clin Pharmacokinet. 1981 Jul-Aug;6(4):245-58. doi: 10.2165/00003088-198106040-00001. (PubMed ID 7249487)" href="#reference-A177874">2</a></sup> and placenta.<sup class="text-reference-group"><a class="reference-popover-link" data-content="Indomethacin Capsules (25 mg) - FDA Label" href="#reference-L6778">13</a></sup> Although indometacin has been shown to cross the blood-brain barrier (BBB)<sup class="text-reference-group"><a class="reference-popover-link" data-content="Indomethacin Capsules (25 mg) - FDA Label" href="#reference-L6778">13</a></sup>, its extensive plasma protein binding allows only the small fraction of free or unbound indometacin to diffuse across the BBB.<sup class="text-reference-group"><a class="reference-popover-link" data-content="Weber M, Kodjikian L, Kruse FE, Zagorski Z, Allaire CM: Efficacy and safety of indomethacin 0.1% eye drops compared with ketorolac 0.5% eye drops in the management of ocular inflammation after cataract surgery. Acta Ophthalmol. 2013 Feb;91(1):e15-21. doi: 10.1111/j.1755-3768.2012.02520.x. Epub 2012 Sep 12. (PubMed ID 22970738)" href="#reference-A177949">6</a></sup></p>