<p>Losartan has a total plasma clearance of 600mL/min and a renal clearance of 75mL/min.<sup class="text-reference-group"><a class="reference-popover-link" data-content="Sica DA, Gehr TW, Ghosh S: Clinical pharmacokinetics of losartan. Clin Pharmacokinet. 2005;44(8):797-814. (PubMed ID 16029066)" href="#reference-A1033">1</a></sup> E-3174, the active metabolite, has a total plasma clearance of 50mL/min and a renal clearance of 25mL/min.<sup class="text-reference-group"><a class="reference-popover-link" data-content="Sica DA, Gehr TW, Ghosh S: Clinical pharmacokinetics of losartan. Clin Pharmacokinet. 2005;44(8):797-814. (PubMed ID 16029066)" href="#reference-A1033">1</a></sup></p>