<p>The metabolism of furosemide occurs mainly in the kidneys and the liver, to a smaller extent. The kidneys are responsible for about 85% of total furosemide total clearance, where about 40% involves biotransformation.<sup class="text-reference-group"><a class="reference-popover-link" data-content="Pichette V, du Souich P: Role of the kidneys in the metabolism of furosemide: its inhibition by probenecid. J Am Soc Nephrol. 1996 Feb;7(2):345-9. (PubMed ID 8785407)" href="#reference-A183563">5</a></sup> Two major metabolites of furosemide are furosemide glucuronide, which is pharmacologically active, and saluamine (CSA) or 4-chloro-5-sulfamoylanthranilic acid.<sup class="text-reference-group"><a class="reference-popover-link" data-content="Ponto LL, Schoenwald RD: Furosemide (frusemide). A pharmacokinetic/pharmacodynamic review (Part I). Clin Pharmacokinet. 1990 May;18(5):381-408. doi: 10.2165/00003088-199018050-00004. (PubMed ID 2185908)" href="#reference-A183281">2</a></sup></p><p class="d-none d-sm-block"><strong>Hover over products below to view reaction partners</strong></p>