<p>Diclofenac is mainly eliminated via metabolism.<sup class="text-reference-group"><a class="reference-popover-link" data-content="Davies NM, Anderson KE: Clinical pharmacokinetics of diclofenac. Therapeutic insights and pitfalls. Clin Pharmacokinet. 1997 Sep;33(3):184-213. doi: 10.2165/00003088-199733030-00003. (PubMed ID 9314611)" href="#reference-A178633">7</a>,<a class="reference-popover-link" data-content="Todd PA, Sorkin EM: Diclofenac sodium. A reappraisal of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy. Drugs. 1988 Mar;35(3):244-85. doi: 10.2165/00003495-198835030-00004. (PubMed ID 3286213)" href="#reference-A180694">8</a></sup> Of the total dose, 60-70% is eliminated in the urine and 30% is eliminated in the feces. No significant enterohepatic recycling occurs.</p>