<p>Adenosine can be phosphorylated by adenosine kinase to form adenosine monophosphate.<sup class="text-reference-group"><a class="reference-popover-link" data-content="Boison D, Yegutkin GG: Adenosine Metabolism: Emerging Concepts for Cancer Therapy. Cancer Cell. 2019 Dec 9;36(6):582-596. doi: 10.1016/j.ccell.2019.10.007. (PubMed ID 31821783)" href="#reference-A229788">1</a>,<a class="reference-popover-link" data-content="FDA Approved Drug Products: Adenoscan (Adenosine) Intravenous Injection (Discontinued)" href="#reference-L31983">12</a></sup> From there, it is phosphorylated again by adenylate kinase 1 to form adenosine diphosphate, and again by nucleoside diphosphate kinase A or B to form adenosine triphosphate.<sup class="text-reference-group"><a class="reference-popover-link" data-content="Boison D, Yegutkin GG: Adenosine Metabolism: Emerging Concepts for Cancer Therapy. Cancer Cell. 2019 Dec 9;36(6):582-596. doi: 10.1016/j.ccell.2019.10.007. (PubMed ID 31821783)" href="#reference-A229788">1</a>,<a class="reference-popover-link" data-content="FDA Approved Drug Products: Adenoscan (Adenosine) Intravenous Injection (Discontinued)" href="#reference-L31983">12</a></sup></p><p>Alternatively, adenosine can be deaminated by adenosine deaminase to form inosine.<sup class="text-reference-group"><a class="reference-popover-link" data-content="Boison D, Yegutkin GG: Adenosine Metabolism: Emerging Concepts for Cancer Therapy. Cancer Cell. 2019 Dec 9;36(6):582-596. doi: 10.1016/j.ccell.2019.10.007. (PubMed ID 31821783)" href="#reference-A229788">1</a>,<a class="reference-popover-link" data-content="FDA Approved Drug Products: Adenoscan (Adenosine) Intravenous Injection (Discontinued)" href="#reference-L31983">12</a></sup> Iosine is phosphorylated by purine nucleoside phosphorylase to form hypoxanthine.<sup class="text-reference-group"><a class="reference-popover-link" data-content="Boison D, Yegutkin GG: Adenosine Metabolism: Emerging Concepts for Cancer Therapy. Cancer Cell. 2019 Dec 9;36(6):582-596. doi: 10.1016/j.ccell.2019.10.007. (PubMed ID 31821783)" href="#reference-A229788">1</a>,<a class="reference-popover-link" data-content="FDA Approved Drug Products: Adenoscan (Adenosine) Intravenous Injection (Discontinued)" href="#reference-L31983">12</a></sup> Hypoxanthine undergoes oxidation by xanthine dehydrogenase twice to form the metabolites xanthine, followed by uric acid.<sup class="text-reference-group"><a class="reference-popover-link" data-content="Maiuolo J, Oppedisano F, Gratteri S, Muscoli C, Mollace V: Regulation of uric acid metabolism and excretion. Int J Cardiol. 2016 Jun 15;213:8-14. doi: 10.1016/j.ijcard.2015.08.109. Epub 2015 Aug 14. (PubMed ID 26316329)" href="#reference-A229793">2</a>,<a class="reference-popover-link" data-content="FDA Approved Drug Products: Adenoscan (Adenosine) Intravenous Injection (Discontinued)" href="#reference-L31983">12</a></sup></p><p class="d-none d-sm-block"><strong>Hover over products below to view reaction partners</strong></p>