<p>Indometacin is a weak organic acid that is 90-99% bound to protein in plasma over the expected range of therapeutic plasma concentrations <sup class="text-reference-group"><a class="reference-popover-link" data-content="Weber M, Kodjikian L, Kruse FE, Zagorski Z, Allaire CM: Efficacy and safety of indomethacin 0.1% eye drops compared with ketorolac 0.5% eye drops in the management of ocular inflammation after cataract surgery. Acta Ophthalmol. 2013 Feb;91(1):e15-21. doi: 10.1111/j.1755-3768.2012.02520.x. Epub 2012 Sep 12. (PubMed ID 22970738)" href="#reference-A177949">6</a>,<a class="reference-popover-link" data-content="Indomethacin Capsules (25 mg) - FDA Label" href="#reference-L6778">13</a></sup>. Like other NSAIDs, indometacin is bound to plasma albumin <sup class="text-reference-group"><a class="reference-popover-link" data-content="Weber M, Kodjikian L, Kruse FE, Zagorski Z, Allaire CM: Efficacy and safety of indomethacin 0.1% eye drops compared with ketorolac 0.5% eye drops in the management of ocular inflammation after cataract surgery. Acta Ophthalmol. 2013 Feb;91(1):e15-21. doi: 10.1111/j.1755-3768.2012.02520.x. Epub 2012 Sep 12. (PubMed ID 22970738)" href="#reference-A177949">6</a></sup> but it does not bind to red blood cells. <sup class="text-reference-group"><a class="reference-popover-link" data-content="Helleberg L: Clinical Pharmacokinetics of indomethacin. Clin Pharmacokinet. 1981 Jul-Aug;6(4):245-58. doi: 10.2165/00003088-198106040-00001. (PubMed ID 7249487)" href="#reference-A177874">2</a></sup></p>