<p>Both lovastatin and its β-hydroxy acid metabolite are highly bound (&gt;95%) to human plasma proteins, largely due to its lipophilicity. Animal studies demonstrated that lovastatin crosses the blood-brain and placental barriers.<sup class="text-reference-group"><a class="reference-popover-link" data-content="FDA Label - Lovastatin" href="#reference-F4661">43</a>,<a class="reference-popover-link" data-content="Health Canada Monograph - Lovastatin" href="#reference-F4664">44</a></sup></p>