<p>The mean elimination half-life of carbamazepine was 35 to 40 hours after one dose of carbamazepine extended-release formulations. The half-life ranged from 12-17 hours after several doses of carbamazepine.<sup class="text-reference-group"><a class="reference-popover-link" data-content="FDA Approved Drug Products: EQUETRO (carbamazepine) extended-release capsules" href="#reference-L1335">16</a></sup> One pharmacokinetic study determined the elimination half-life of carbamazepine to range between 27 to 36.8 hours in healthy volunteers.<sup class="text-reference-group"><a class="reference-popover-link" data-content="Rawlins MD, Collste P, Bertilsson L, Palmer L: Distribution and elimination kinetics of carbamazepine in man. Eur J Clin Pharmacol. 1975 Feb 28;8(2):91-6. (PubMed ID 1233212)" href="#reference-A180424">11</a></sup></p>