<p>There is limited information in the literature regarding the metabolism of cysteamine. This drug undergoes significant first-pass metabolism.<sup class="text-reference-group"><a class="reference-popover-link" data-content="Dohil R, Cabrera BL, Gangoiti JA, Barshop BA, Rioux P: Pharmacokinetics of cysteamine bitartrate following intraduodenal delivery. Fundam Clin Pharmacol. 2014 Apr;28(2):136-43. doi: 10.1111/fcp.12009. Epub 2012 Oct 31. (PubMed ID 23113697)" href="#reference-A218946">8</a></sup></p>