<p>Imipramine has a mean half life of 12 h. Its active metabolite, desipramine has a mean half life of 22.5 h <sup class="text-reference-group"><a class="reference-popover-link" data-content="Sallee FR, Pollock BG: Clinical pharmacokinetics of imipramine and desipramine. Clin Pharmacokinet. 1990 May;18(5):346-64. (PubMed ID 2185906)" href="#reference-A31907">3</a></sup>.</p>