<p>Indometacin disposition from the plasma is reported to be biphasic, with a half-life of 1 hour during the initial phase and 2.6–11.2 hours during the second phase.<sup class="text-reference-group"><a class="reference-popover-link" data-content="Weber M, Kodjikian L, Kruse FE, Zagorski Z, Allaire CM: Efficacy and safety of indomethacin 0.1% eye drops compared with ketorolac 0.5% eye drops in the management of ocular inflammation after cataract surgery. Acta Ophthalmol. 2013 Feb;91(1):e15-21. doi: 10.1111/j.1755-3768.2012.02520.x. Epub 2012 Sep 12. (PubMed ID 22970738)" href="#reference-A177949">6</a></sup> Interindividual and intraindividual variations are possible due to the extensive and sporadic nature of the enterohepatic recycling and biliary discharge of the drug.<sup class="text-reference-group"><a class="reference-popover-link" data-content="Helleberg L: Clinical Pharmacokinetics of indomethacin. Clin Pharmacokinet. 1981 Jul-Aug;6(4):245-58. doi: 10.2165/00003088-198106040-00001. (PubMed ID 7249487)" href="#reference-A177874">2</a>,<a class="reference-popover-link" data-content="Weber M, Kodjikian L, Kruse FE, Zagorski Z, Allaire CM: Efficacy and safety of indomethacin 0.1% eye drops compared with ketorolac 0.5% eye drops in the management of ocular inflammation after cataract surgery. Acta Ophthalmol. 2013 Feb;91(1):e15-21. doi: 10.1111/j.1755-3768.2012.02520.x. Epub 2012 Sep 12. (PubMed ID 22970738)" href="#reference-A177949">6</a></sup></p><p>The mean half-life of oral indomethacin is estimated to be about 4.5 hours.<sup class="text-reference-group"><a class="reference-popover-link" data-content="Indomethacin Capsules (25 mg) - FDA Label" href="#reference-L6778">13</a></sup> The disposition of intravenous indometacin in preterm neonates was shown to vary across premature infants. In neonates older than 7 days, the mean plasma half-life of intravenous indometacin was approximately 20 hours, ranging from 15 hours in infants weighing more than 1000 g and 21 hours in infants weighing less than 1000 g.<sup class="text-reference-group"><a class="reference-popover-link" data-content="Indocin I.V. (indomethacin for injection) - FDA Label" href="#reference-L10553">14</a></sup></p>