<p>Data regarding acute overdoses of glucocorticoids are rare.<sup class="text-reference-group"><a class="reference-popover-link" data-content="FDA Approved Drug Products: Vosol Hydrocortisone and Glacial Acetic Acid Otic Drops" href="#reference-L10529">14</a>,<a class="reference-popover-link" data-content="FDA Approved Drug Products: Casporyn Neomycin Sulfate, Polymixin B Sulfate, and Hydrocortisone Otic Drops" href="#reference-L10532">15</a>,<a class="reference-popover-link" data-content="FDA Approved Drug Products: Cortef Hydrocortisone Oral Tablets" href="#reference-L10535">16</a>,<a class="reference-popover-link" data-content="FDA Approved Drug Products: Cortenema Hydrocortisone Rectal Enema" href="#reference-L10538">17</a>,<a class="reference-popover-link" data-content="FDA Approved Drug Products: Bacitracin, Neomycin, Polymyxin B, and Hydrocortisone Topical Ointment" href="#reference-L7772">18</a>,<a class="reference-popover-link" data-content="FDA Approved Drug Products: Xerese (Acyclovir and Hydrocortisone) Topical Cream" href="#reference-L7321">19</a></sup> Chronic high doses of glucocorticoids can lead to the development of cataract, glaucoma, hypertension, water retention, hyperlipidemia, peptic ulcer, pancreatitis, myopathy, osteoporosis, mood changes, psychosis, dermal atrophy, allergy, acne, hypertrichosis, immune suppression, decreased resistance to infection, moon face, hyperglycemia, hypocalcemia, hypophosphatemia, metabolic acidosis, growth suppression, and secondary adrenal insufficiency.<sup class="text-reference-group"><a class="reference-popover-link" data-content="Ciriaco M, Ventrice P, Russo G, Scicchitano M, Mazzitello G, Scicchitano F, Russo E: Corticosteroid-related central nervous system side effects. J Pharmacol Pharmacother. 2013 Dec;4(Suppl 1):S94-8. doi: 10.4103/0976-500X.120975. (PubMed ID 24347992)" href="#reference-A188405">8</a></sup> Overdose may be treated by adjusting the dose or stopping the corticosteroid as well as initiating symptomatic and supportive treatment.<sup class="text-reference-group"><a class="reference-popover-link" data-content="Ciriaco M, Ventrice P, Russo G, Scicchitano M, Mazzitello G, Scicchitano F, Russo E: Corticosteroid-related central nervous system side effects. J Pharmacol Pharmacother. 2013 Dec;4(Suppl 1):S94-8. doi: 10.4103/0976-500X.120975. (PubMed ID 24347992)" href="#reference-A188405">8</a></sup></p>