<p>Corticosteroids are generally bound to corticosteroid binding globulin<sup class="text-reference-group"><a class="reference-popover-link" data-content="Gardill BR, Vogl MR, Lin HY, Hammond GL, Muller YA: Corticosteroid-binding globulin: structure-function implications from species differences. PLoS One. 2012;7(12):e52759. doi: 10.1371/journal.pone.0052759. Epub 2012 Dec 26. (PubMed ID 23300763)" href="#reference-A187439">11</a></sup> and serum albumin<sup class="text-reference-group"><a class="reference-popover-link" data-content="Czock D, Keller F, Rasche FM, Haussler U: Pharmacokinetics and pharmacodynamics of systemically administered glucocorticoids. Clin Pharmacokinet. 2005;44(1):61-98. doi: 10.2165/00003088-200544010-00003. (PubMed ID 15634032)" href="#reference-A187436">12</a></sup> in plasma. Hydrocortisone is 90.1% bound to proteins in plasma, with 56.2% bound to albumin.<sup class="text-reference-group"><a class="reference-popover-link" data-content="FLORINI JR, BUYSKE DA: Plasma protein binding of triamcinolone-H3 and hydrocortisone-4-C14. J Biol Chem. 1961 Jan;236:247-51. (PubMed ID 13700365)" href="#reference-A184223">5</a></sup></p>