<p>Spironolactone reaches a maximum concentration in 2.6 hours and an active metabolite (canrenone) reaches a maximum concentration in 4.3 hours.<sup class="text-reference-group"><a class="reference-popover-link" data-content="Official drug label" href="#label-reference">Label</a></sup> When taken with food, the bioavailability of spironolactone increases to 95.4%.<sup class="text-reference-group"><a class="reference-popover-link" data-content="Official drug label" href="#label-reference">Label</a></sup></p><p>Giving spironolactone with food increases the maximum concentration from 209ng/mL to 301ng/mL.<sup class="text-reference-group"><a class="reference-popover-link" data-content="Karim A: Spironolactone: disposition, metabolism, pharmacodynamics, and bioavailability. Drug Metab Rev. 1978;8(1):151-88. doi: 10.3109/03602537808993782. (PubMed ID 363379)" href="#reference-A178165">6</a></sup> The time to maximum concentration also increases from 2.28 hours to 3.05 hours.<sup class="text-reference-group"><a class="reference-popover-link" data-content="Karim A: Spironolactone: disposition, metabolism, pharmacodynamics, and bioavailability. Drug Metab Rev. 1978;8(1):151-88. doi: 10.3109/03602537808993782. (PubMed ID 363379)" href="#reference-A178165">6</a></sup> The area under the curve varies from 2103ng/mL*hr to 4544ng/mL*hr.<sup class="text-reference-group"><a class="reference-popover-link" data-content="Karim A: Spironolactone: disposition, metabolism, pharmacodynamics, and bioavailability. Drug Metab Rev. 1978;8(1):151-88. doi: 10.3109/03602537808993782. (PubMed ID 363379)" href="#reference-A178165">6</a></sup></p>