<p>Patients experiencing an overdose of adenosine may present with asystole, heart block, or cardiac ischemia; though the effects are generally short lived.<sup class="text-reference-group"><a class="reference-popover-link" data-content="Singh S, McKintosh R: Adenosine . (PubMed ID 30085591)" href="#reference-A187466">4</a></sup> Patients experiencing an overdose should be treated with symptomatic and supportive care, which may include a slow intravenous injection of <a href="https://go.drugbank.com/drugs/DB00277">theophylline</a>.<sup class="text-reference-group"><a class="reference-popover-link" data-content="FDA Approved Drug Products: Adenoscan (Adenosine) Intravenous Injection (Discontinued)" href="#reference-L31983">12</a></sup></p><p>The LD<sub>50</sub> in mice is &gt;20 g/kg subcutaneously, 500mg/kg intraperitoneally, and 39.6 µg/kg subcutaneously.<sup class="text-reference-group"><a class="reference-popover-link" data-content="Cayman Chemical: Adenosine MSDS" href="#reference-L32048">14</a></sup></p>