<p>The volume of distribution of losartan is 34.4±17.9L and 10.3±1.1L for the active metabolite (E-3174).<sup class="text-reference-group"><a class="reference-popover-link" data-content="Sica DA, Gehr TW, Ghosh S: Clinical pharmacokinetics of losartan. Clin Pharmacokinet. 2005;44(8):797-814. (PubMed ID 16029066)" href="#reference-A1033">1</a></sup></p>