<p>Imipramine is nearly exclusively metabolized by the liver <sup class="text-reference-group"><a class="reference-popover-link" data-content="Sallee FR, Pollock BG: Clinical pharmacokinetics of imipramine and desipramine. Clin Pharmacokinet. 1990 May;18(5):346-64. (PubMed ID 2185906)" href="#reference-A31907">3</a></sup>. Imipramine is converted to desipramine by CYP1A2, CYP3A4, CYP2C19. Both imipramine and desipramine are hydroxylated by CYP2D6 <sup class="text-reference-group"><a class="reference-popover-link" data-content="Gardiner SJ, Begg EJ: Pharmacogenetics, drug-metabolizing enzymes, and clinical practice. Pharmacol Rev. 2006 Sep;58(3):521-90. doi: 10.1124/pr.58.3.6. (PubMed ID 16968950)" href="#reference-A31915">4</a></sup>. Desipramine is an active metabolite.</p><p>Minor metabolic pathways include dealkylation to form an imidodibenzyl product as well as demethylation of desipramine to didemethylimipramine and subsequent hydroxylation <sup class="text-reference-group"><a class="reference-popover-link" data-content="Sallee FR, Pollock BG: Clinical pharmacokinetics of imipramine and desipramine. Clin Pharmacokinet. 1990 May;18(5):346-64. (PubMed ID 2185906)" href="#reference-A31907">3</a></sup>.</p><p>Less than 5% of orally administered imipramine is excreted unchanged.</p><p class="d-none d-sm-block"><strong>Hover over products below to view reaction partners</strong></p>