Interacting Gene/EnzymeAllele nameGenotype(s)Defining Change(s)Type(s)DescriptionDetailsDNA polymerase subunit gamma-1A467T(A;A) / (A;G)G > AADR Directly StudiedThe presence of this polymorphism in POLG may indicate an increased risk of liver failure and death when treated with valproic acid.DetailsDNA polymerase subunit gamma-1W748S(C;C) / (C;G)G > CADR Directly StudiedThe presence of this polymorphism in POLG may indicate an increased risk of liver failure and death when treated with valproic acid.Details