<p>Doxycycline is metabolized in the liver and gastrointestinal tract and concentrated in bile <sup class="text-reference-group"><a class="reference-popover-link" data-content="Official drug label" href="#label-reference">Label</a></sup>, <sup class="text-reference-group"><a class="reference-popover-link" data-content="Doxycycline EMA label" href="#reference-F3055">16</a></sup>.
Major metabolic pathways of doxycycline have not been identified, however, enzyme inducers have been found to decrease the half-life of doxycycline <sup class="text-reference-group"><a class="reference-popover-link" data-content="Doxycycline EMA label" href="#reference-F3055">16</a></sup>.</p>