<p>Diclofenac is indicated for use in the treatment of pain and inflammation from varying sources including inflammatory conditions such as osteoarthritis, rheumatoid arthritis, and akylosing spondylitis, as well as injury-related inflammation due to surgery and physical trauma. It is often used in combination with <a href="https://go.drugbank.com/drugs/DB00929">misoprostol</a> as a gastro-protective agent in patients with high risk of developing NSAID-induced ulcers.</p>