<p>Oral hydrocortisone at a dose of 0.2-0.3mg/kg/day reached a mean C<sub>max</sub> of 32.69nmol/L with a mean AUC of 90.63h*nmol/L<sup class="text-reference-group"><a class="reference-popover-link" data-content="Werumeus Buning J, Touw DJ, Brummelman P, Dullaart RPF, van den Berg G, van der Klauw MM, Kamp J, Wolffenbuttel BHR, van Beek AP: Pharmacokinetics of oral hydrocortisone - Results and implications from a randomized controlled trial. Metabolism. 2017 Jun;71:7-16. doi: 10.1016/j.metabol.2017.02.005. Epub 2017 Feb 13. (PubMed ID 28521880)" href="#reference-A188354">1</a></sup> A 0.4-0.6mg/kg/day dose reached a mean C<sub>max</sub> of 70.81nmol/L with a mean AUC of 199.11h*nmol/L.<sup class="text-reference-group"><a class="reference-popover-link" data-content="Werumeus Buning J, Touw DJ, Brummelman P, Dullaart RPF, van den Berg G, van der Klauw MM, Kamp J, Wolffenbuttel BHR, van Beek AP: Pharmacokinetics of oral hydrocortisone - Results and implications from a randomized controlled trial. Metabolism. 2017 Jun;71:7-16. doi: 10.1016/j.metabol.2017.02.005. Epub 2017 Feb 13. (PubMed ID 28521880)" href="#reference-A188354">1</a></sup> However, the pharmacokinetics of hydrocortisone can vary by 10 times from patient to patient.<sup class="text-reference-group"><a class="reference-popover-link" data-content="Werumeus Buning J, Touw DJ, Brummelman P, Dullaart RPF, van den Berg G, van der Klauw MM, Kamp J, Wolffenbuttel BHR, van Beek AP: Pharmacokinetics of oral hydrocortisone - Results and implications from a randomized controlled trial. Metabolism. 2017 Jun;71:7-16. doi: 10.1016/j.metabol.2017.02.005. Epub 2017 Feb 13. (PubMed ID 28521880)" href="#reference-A188354">1</a></sup></p><p>Topical hydrocortisone cream is 4-19% bioavailable[8546995] with a T<sub>max</sub> of 24h.<sup class="text-reference-group"><a class="reference-popover-link" data-content="Aalto-Korte K, Turpeinen M: Pharmacokinetics of topical hydrocortisone at plasma level after applications once or twice daily in patients with widespread dermatitis. Br J Dermatol. 1995 Aug;133(2):259-63. doi: 10.1111/j.1365-2133.1995.tb02625.x. (PubMed ID 7547394)" href="#reference-A188372">2</a></sup></p><p>Hydrocortisone retention enemas are have a bioavailability of 0.810 for slow absorbers and 0.502 in rapid absorbers.<sup class="text-reference-group"><a class="reference-popover-link" data-content="Lima JJ, Jusko WJ: Bioavailability of hydrocortisone retention enemas in relation to absorption kinetics. Clin Pharmacol Ther. 1980 Aug;28(2):262-9. doi: 10.1038/clpt.1980.159. (PubMed ID 7398193)" href="#reference-A188378">4</a></sup> Slow absorbers take up hydrocortisone at a rate of 0.361±0.255/h while fast absorbers take up hydrocortisone at a rate of 1.05±0.255/h.<sup class="text-reference-group"><a class="reference-popover-link" data-content="Lima JJ, Jusko WJ: Bioavailability of hydrocortisone retention enemas in relation to absorption kinetics. Clin Pharmacol Ther. 1980 Aug;28(2):262-9. doi: 10.1038/clpt.1980.159. (PubMed ID 7398193)" href="#reference-A188378">4</a></sup></p><p>A 20mg IV dose of hydrocortisone has an AUC of 1163±277ng*h/mL.<sup class="text-reference-group"><a class="reference-popover-link" data-content="Derendorf H, Mollmann H, Barth J, Mollmann C, Tunn S, Krieg M: Pharmacokinetics and oral bioavailability of hydrocortisone. J Clin Pharmacol. 1991 May;31(5):473-6. doi: 10.1002/j.1552-4604.1991.tb01906.x. (PubMed ID 2050835)" href="#reference-A188381">6</a></sup></p>