<p>Apparent clearance (CL/F), single oral 200 mg dose, healthy subjects = 27.7 L/hr.<sup class="text-reference-group"><a class="reference-popover-link" data-content="FDA Approved Drug Products: CELEBREX (celecoxib) oral capsules" href="#reference-L7646">31</a></sup> Clearance may be decreased by about 47% in patients with chronic renal insufficiency, according to a pharmacokinetic study. Studies have not been performed in patients with severe renal impairment.<sup class="text-reference-group"><a class="reference-popover-link" data-content="FDA Approved Drug Products: CELEBREX (celecoxib) oral capsules" href="#reference-L7646">31</a></sup></p>