<p>Minocycline is predominantly eliminated through the biliary route.<sup class="text-reference-group"><a class="reference-popover-link" data-content="Welling PG, Shaw WR, Uman SJ, Tse FL, Craig WA: Pharmacokinetics of minocycline in renal failure. Antimicrob Agents Chemother. 1975 Nov;8(5):532-7. doi: 10.1128/aac.8.5.532. (PubMed ID 1211910)" href="#reference-A190699">3</a></sup> 4.5-9% of an intravenous minocycline dose is recovered in the urine.<sup class="text-reference-group"><a class="reference-popover-link" data-content="Simon C, Malerczyk V, Preuss I, Schmidt K, Grahmann H: [Activity in vitro and pharmacokinetics of minocycline (author's transl)]. Arzneimittelforschung. 1976 Apr;26(4):556-60. (PubMed ID 782466)" href="#reference-A190702">4</a>,<a class="reference-popover-link" data-content="Saivin S, Houin G: Clinical pharmacokinetics of doxycycline and minocycline. Clin Pharmacokinet. 1988 Dec;15(6):355-66. doi: 10.2165/00003088-198815060-00001. (PubMed ID 3072140)" href="#reference-A190708">5</a></sup> 10-19.5% of an oral dose is recovered in the urine and 20-34% is recovered in the feces.<sup class="text-reference-group"><a class="reference-popover-link" data-content="Saivin S, Houin G: Clinical pharmacokinetics of doxycycline and minocycline. Clin Pharmacokinet. 1988 Dec;15(6):355-66. doi: 10.2165/00003088-198815060-00001. (PubMed ID 3072140)" href="#reference-A190708">5</a></sup></p>