<p>Imipramine has a high apparent volume of distribution of 10-20 L/kg <sup class="text-reference-group"><a class="reference-popover-link" data-content="Sallee FR, Pollock BG: Clinical pharmacokinetics of imipramine and desipramine. Clin Pharmacokinet. 1990 May;18(5):346-64. (PubMed ID 2185906)" href="#reference-A31907">3</a></sup>. The drug is known to accumulate in the brain at concentrations 30-40 times that in systemic circulation.</p>