<p>Morphine is 90% metabolized by glucuronidation by UGT2B7 and sulfation at positions 3 and 6.<sup class="text-reference-group"><a class="reference-popover-link" data-content="Klimas R, Mikus G: Morphine-6-glucuronide is responsible for the analgesic effect after morphine administration: a quantitative review of morphine, morphine-6-glucuronide, and morphine-3-glucuronide. Br J Anaesth. 2014 Dec;113(6):935-44. doi: 10.1093/bja/aeu186. Epub 2014 Jul 1. (PubMed ID 24985077)" href="#reference-A176059">4</a></sup> Morphine can also be metabolized to codeine, normorphine, and morphine ethereal sulfate.<sup class="text-reference-group"><a class="reference-popover-link" data-content="Hoskin PJ, Hanks GW: Morphine: pharmacokinetics and clinical practice. Br J Cancer. 1990 Nov;62(5):705-7. (PubMed ID 2245160)" href="#reference-A176119">6</a></sup></p><p class="d-none d-sm-block"><strong>Hover over products below to view reaction partners</strong></p>