<p>Diclofenac is over 99.7% bound to serum proteins, primarily albumin.<sup class="text-reference-group"><a class="reference-popover-link" data-content="Davies NM, Anderson KE: Clinical pharmacokinetics of diclofenac. Therapeutic insights and pitfalls. Clin Pharmacokinet. 1997 Sep;33(3):184-213. doi: 10.2165/00003088-199733030-00003. (PubMed ID 9314611)" href="#reference-A178633">7</a></sup> It is undergoes limited binding to lipoproteins as well with 1.1% bound to HDL, 0.3% to LDL, and 0.15% to VLDL.</p>