<p>Meloxicam is almost completely metabolized. CYP2C9 is the main enzyme responsible for the metabolism of meloxicam<sup class="text-reference-group"><a class="reference-popover-link" data-content="Bekker A, Kloepping C, Collingwood S: Meloxicam in the management of post-operative pain: Narrative review. J Anaesthesiol Clin Pharmacol. 2018 Oct-Dec;34(4):450-457. doi: 10.4103/joacp.JOACP_133_18. (PubMed ID 30774225)" href="#reference-A190189">1</a>,<a class="reference-popover-link" data-content="Chesne C, Guyomard C, Guillouzo A, Schmid J, Ludwig E, Sauter T: Metabolism of Meloxicam in human liver involves cytochromes P4502C9 and 3A4. Xenobiotica. 1998 Jan;28(1):1-13. doi: 10.1080/004982598239704. (PubMed ID 9493314)" href="#reference-A14902">6</a></sup> with minor contributions from CYP3A4.<sup class="text-reference-group"><a class="reference-popover-link" data-content="FDA approved products: Mobic (meloxicam) oral tablets" href="#reference-L11398">10</a></sup> Meloxicam has 4 major metabolites with no activity determined. About 60% of the ingested dose is metabolized to 5'-carboxy meloxicam from hepatic cytochrome enzyme oxidation of an intermediate metabolite, 5’-hydroxymethylmeloxicam.<sup class="text-reference-group"><a class="reference-popover-link" data-content="Chesne C, Guyomard C, Guillouzo A, Schmid J, Ludwig E, Sauter T: Metabolism of Meloxicam in human liver involves cytochromes P4502C9 and 3A4. Xenobiotica. 1998 Jan;28(1):1-13. doi: 10.1080/004982598239704. (PubMed ID 9493314)" href="#reference-A14902">6</a>,<a class="reference-popover-link" data-content="Prasad GS, Srisailam K, Sashidhar RB: Metabolic inhibition of meloxicam by specific CYP2C9 inhibitors in Cunninghamella blakesleeana NCIM 687: in silico and in vitro studies. Springerplus. 2016 Feb 24;5:166. doi: 10.1186/s40064-016-1794-4. eCollection 2016. (PubMed ID 27026863)" href="#reference-A39443">8</a></sup> Two other metabolites are likely produced via peroxidation.<sup class="text-reference-group"><a class="reference-popover-link" data-content="Chesne C, Guyomard C, Guillouzo A, Schmid J, Ludwig E, Sauter T: Metabolism of Meloxicam in human liver involves cytochromes P4502C9 and 3A4. Xenobiotica. 1998 Jan;28(1):1-13. doi: 10.1080/004982598239704. (PubMed ID 9493314)" href="#reference-A14902">6</a>,<a class="reference-popover-link" data-content="FDA approved products: Mobic (meloxicam) oral tablets" href="#reference-L11398">10</a></sup></p><p class="d-none d-sm-block"><strong>Hover over products below to view reaction partners</strong></p>