<p>Rapidly and well absorbed (&gt;95%) after oral administration <sup class="text-reference-group"><a class="reference-popover-link" data-content="Sallee FR, Pollock BG: Clinical pharmacokinetics of imipramine and desipramine. Clin Pharmacokinet. 1990 May;18(5):346-64. (PubMed ID 2185906)" href="#reference-A31907">3</a></sup>. The primary site of absorption is the small intestine as the basic amine groups are ionized in the acidic environment of the stomach, preventing movement across tissues. Bioavailability ranges from 29-77% due to high inter-individual variability. Peak plasma concentration is usually attained 2-6 hours following oral administration. Absorption is unaffected by food. </p>