<p>The kidneys are responsible for 85% of total furosemide total clearance, where about 43% of the drug undergoes renal excretion.<sup class="text-reference-group"><a class="reference-popover-link" data-content="Pichette V, du Souich P: Role of the kidneys in the metabolism of furosemide: its inhibition by probenecid. J Am Soc Nephrol. 1996 Feb;7(2):345-9. (PubMed ID 8785407)" href="#reference-A183563">5</a></sup> Significantly more furosemide is excreted in urine following the I.V. injection than after the tablet or oral solution. Approximately 50% of the furosemide load is excreted unchanged in urine, and the rest is metabolized into glucuronide in the kidney.<sup class="text-reference-group"><a class="reference-popover-link" data-content="Oh SW, Han SY: Loop Diuretics in Clinical Practice. Electrolyte Blood Press. 2015 Jun;13(1):17-21. doi: 10.5049/EBP.2015.13.1.17. Epub 2015 Jun 30. (PubMed ID 26240596)" href="#reference-A31831">4</a></sup></p>