<p>The elimination half-life of oral erythromycin was 3.5 hours according to one study<sup class="text-reference-group"><a class="reference-popover-link" data-content="Amsden GW: Erythromycin, clarithromycin, and azithromycin: are the differences real? Clin Ther. 1996 Jan-Feb;18(1):56-72; discussion 55. (PubMed ID 8851453)" href="#reference-A174451">6</a></sup> and ranged between 2.4-3.1 hours in another study.<sup class="text-reference-group"><a class="reference-popover-link" data-content="Wang LQ, Hu ZY, Yu Q, Guo X, Xiong J, Huang ZZ, Cheng ZN: [Pharmacokinetics of erythromycin stinoprate capsule]. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2005 Apr;30(2):197-201. (PubMed ID 15898434)" href="#reference-A180598">15</a></sup> Repetitive dosing of erythromycin leads to increased elimination half-life.<sup class="text-reference-group"><a class="reference-popover-link" data-content="Colburn WA, Di Santo AR, Gibaldi M: Pharmacokinetics of erythromycin on repetitive dosing. J Clin Pharmacol. 1977 Oct;17(10 Pt 1):592-600. (PubMed ID 915023)" href="#reference-A180601">16</a></sup> </p>