<p>Tetracyclines, such as doxycycline, are readily absorbed and are bound to plasma proteins by varying degrees. Doxycycline is almost completely absorbed after oral administration. This drug is highly lipid soluble and has a low affinity for calcium binding <sup class="text-reference-group"><a class="reference-popover-link" data-content="Official drug label" href="#label-reference">Label</a></sup>. Absorption is not significantly affected by the concomitant ingestion of food or milk <sup class="text-reference-group"><a class="reference-popover-link" data-content="Doxycycline MedSafe NZ" href="#reference-F3052">15</a></sup>. Peak serum levels of approximately 2.6 mcg/ml are reached at 2 hours following a 200 mg tablet oral dose <sup class="text-reference-group"><a class="reference-popover-link" data-content="Doxycycline MedSafe NZ" href="#reference-F3052">15</a></sup>.</p>