<p>High doses of tamoxifen in animals lead to respiratory difficulty and convulsions.<sup class="text-reference-group"><a class="reference-popover-link" data-content="FDA Approved Drug Products: Tamoxifen Oral Tablets" href="#reference-L7799">15</a>,<a class="reference-popover-link" data-content="FDA Approved Drug Products: Tamoxifen Oral Solution" href="#reference-L7802">16</a></sup> High doses in advanced metastatic cancer patients resulted in acute neurotoxicity seen by tremor, hyperreflexia, unsteady gait, and dizziness.<sup class="text-reference-group"><a class="reference-popover-link" data-content="FDA Approved Drug Products: Tamoxifen Oral Tablets" href="#reference-L7799">15</a>,<a class="reference-popover-link" data-content="FDA Approved Drug Products: Tamoxifen Oral Solution" href="#reference-L7802">16</a></sup> Patients experiencing and overdose should be given supportive treatment as no specific treatment for overdose is suggested.<sup class="text-reference-group"><a class="reference-popover-link" data-content="FDA Approved Drug Products: Tamoxifen Oral Tablets" href="#reference-L7799">15</a>,<a class="reference-popover-link" data-content="FDA Approved Drug Products: Tamoxifen Oral Solution" href="#reference-L7802">16</a></sup></p>