<p>Carbamazepine is indicated for the treatment of epilepsy and pain associated with true trigeminal neuralgia.<sup class="text-reference-group"><a class="reference-popover-link" data-content="FDA Approved Drug Products: EQUETRO (carbamazepine) extended-release capsules" href="#reference-L1335">16</a></sup> In particular, carbamazepine has shown efficacy in treating mixed seizures, partial seizures with complex symptoms, and generalized tonic-clonic seizures.<sup class="text-reference-group"><a class="reference-popover-link" data-content="Tolou-Ghamari Z, Zare M, Habibabadi JM, Najafi MR: A quick review of carbamazepine pharmacokinetics in epilepsy from 1953 to 2012. J Res Med Sci. 2013 Mar;18(Suppl 1):S81-5. (PubMed ID 23961295)" href="#reference-A180301">3</a>,<a class="reference-popover-link" data-content="FDA Approved Drug Products: EQUETRO (carbamazepine) extended-release capsules" href="#reference-L1335">16</a></sup> Carbamazepine is also indicated for the treatment of manic episodes and mixed manic-depressive episodes caused by bipolar I disorder.<sup class="text-reference-group"><a class="reference-popover-link" data-content="FDA Approved Drug Products: EQUETRO (carbamazepine) extended-release capsules" href="#reference-L1335">16</a></sup> Some off-label, unapproved uses of carbamazepine include the treatment of alcohol withdrawal syndrome and restless leg syndrome.<sup class="text-reference-group"><a class="reference-popover-link" data-content="Barrons R, Roberts N: The role of carbamazepine and oxcarbazepine in alcohol withdrawal syndrome. J Clin Pharm Ther. 2010 Apr;35(2):153-67. doi: 10.1111/j.1365-2710.2009.01098.x. (PubMed ID 20456734)" href="#reference-A180415">9</a>,<a class="reference-popover-link" data-content="Aurora RN, Kristo DA, Bista SR, Rowley JA, Zak RS, Casey KR, Lamm CI, Tracy SL, Rosenberg RS: The treatment of restless legs syndrome and periodic limb movement disorder in adults--an update for 2012: practice parameters with an evidence-based systematic review and meta-analyses: an American Academy of Sleep Medicine Clinical Practice Guideline. Sleep. 2012 Aug 1;35(8):1039-62. doi: 10.5665/sleep.1988. (PubMed ID 22851801)" href="#reference-A180421">10</a></sup></p>