<p>After an oral dose, the total clearance of meloxicam is 0.42–0.48 L/h.<sup class="text-reference-group"><a class="reference-popover-link" data-content="Bekker A, Kloepping C, Collingwood S: Meloxicam in the management of post-operative pain: Narrative review. J Anaesthesiol Clin Pharmacol. 2018 Oct-Dec;34(4):450-457. doi: 10.4103/joacp.JOACP_133_18. (PubMed ID 30774225)" href="#reference-A190189">1</a>,<a class="reference-popover-link" data-content="Turck D, Roth W, Busch U: A review of the clinical pharmacokinetics of meloxicam. Br J Rheumatol. 1996 Apr;35 Suppl 1:13-6. doi: 10.1093/rheumatology/35.suppl_1.13. (PubMed ID 8630630)" href="#reference-A190195">3</a></sup> The FDA label indicates a plasma clearance from 7 to 9 mL/min. No dose changes are required in mild to moderate renal or hepatic impairment. The use of meloxicam in patients with severe renal or hepatic impairment has not been studied. FDA prescribing information advises against it.<sup class="text-reference-group"><a class="reference-popover-link" data-content="FDA approved products: Mobic (meloxicam) oral tablets" href="#reference-L11398">10</a></sup></p>