<p>Naproxen is classified as a nonsteroidal anti-inflammatory dug (NSAID) and was initially approved for prescription use in 1976 and then for over-the-counter (OTC) use in 1994.<sup class="text-reference-group"><a class="reference-popover-link" data-content="Brutzkus JC, Varacallo M: Naproxen . (PubMed ID 30247840)" href="#reference-A178975">3</a></sup> It can effectively manage acute pain as well as pain related to rheumatic diseases, and has a well studied adverse effect profile.<sup class="text-reference-group"><a class="reference-popover-link" data-content="Todd PA, Clissold SP: Naproxen. A reappraisal of its pharmacology, and therapeutic use in rheumatic diseases and pain states. Drugs. 1990 Jul;40(1):91-137. doi: 10.2165/00003495-199040010-00006. (PubMed ID 2202585)" href="#reference-A179098">5</a></sup> Given its overall tolerability and effectiveness, naproxen can be considered a first line treatment for a variety of clinical situations requiring analgesia.<sup class="text-reference-group"><a class="reference-popover-link" data-content="Todd PA, Clissold SP: Naproxen. A reappraisal of its pharmacology, and therapeutic use in rheumatic diseases and pain states. Drugs. 1990 Jul;40(1):91-137. doi: 10.2165/00003495-199040010-00006. (PubMed ID 2202585)" href="#reference-A179098">5</a></sup> Naproxen is available in both immediate and delayed release formulations, in combination with sumatriptan to treat migraines, and in combination with esomeprazole to lower the risk of developing gastric ulcers.<sup class="text-reference-group"><a class="reference-popover-link" data-content="Naprelan FDA Label" href="#reference-L6582">12</a></sup><sup class="text-reference-group"><a class="reference-popover-link" data-content="Naprosyn FDA Label" href="#reference-L6583">13</a></sup><sup class="text-reference-group"><a class="reference-popover-link" data-content="Treximet FDA Label" href="#reference-L7309">15</a></sup><sup class="text-reference-group"><a class="reference-popover-link" data-content="Vimovo FDA Label" href="#reference-L7312">16</a></sup></p>