<p><strong>Indicated</strong> for:<sup class="text-reference-group"><a class="reference-popover-link" data-content="Official drug label" href="#label-reference">Label</a></sup> </p><p>1) Use as monotherapy or adjunctive therapy in the management of complex partial seizures and simple or complex absence seizures. </p><p>2) Adjunctive therapy in the management of multiple seizure types that include absence seizures. </p><p>3) Prophylaxis of migraine headaches.</p><p>4) Acute management of mania associated with bipolar disorder.</p><p><strong>Off-label</strong> uses include:</p><p>1) Maintenance therapy for bipolar disorder.<sup class="text-reference-group"><a class="reference-popover-link" data-content="Cipriani A, Reid K, Young AH, Macritchie K, Geddes J: Valproic acid, valproate and divalproex in the maintenance treatment of bipolar disorder. Cochrane Database Syst Rev. 2013 Oct 17;(10):CD003196. doi: 10.1002/14651858.CD003196.pub2. (PubMed ID 24132760)" href="#reference-A177919">7</a></sup></p><p>2) Treatment for acute bipolar depression.<sup class="text-reference-group"><a class="reference-popover-link" data-content="Ghaemi SN, Gilmer WS, Goldberg JF, Zablotsky B, Kemp DE, Kelley ME, Bauer AD, Fleck J, Filkowski MM, Stan VA, Dunn RT: Divalproex in the treatment of acute bipolar depression: a preliminary double-blind, randomized, placebo-controlled pilot study. J Clin Psychiatry. 2007 Dec;68(12):1840-4. (PubMed ID 18162014)" href="#reference-A177928">8</a>,<a class="reference-popover-link" data-content="Davis LL, Bartolucci A, Petty F: Divalproex in the treatment of bipolar depression: a placebo-controlled study. J Affect Disord. 2005 Apr;85(3):259-66. doi: 10.1016/j.jad.2004.09.009. (PubMed ID 15780695)" href="#reference-A177931">9</a>,<a class="reference-popover-link" data-content="Muzina DJ, Gao K, Kemp DE, Khalife S, Ganocy SJ, Chan PK, Serrano MB, Conroy CM, Calabrese JR: Acute efficacy of divalproex sodium versus placebo in mood stabilizer-naive bipolar I or II depression: a double-blind, randomized, placebo-controlled trial. J Clin Psychiatry. 2011 Jun;72(6):813-9. doi: 10.4088/JCP.09m05570gre. Epub 2010 Aug 24. (PubMed ID 20816041)" href="#reference-A177934">10</a></sup></p><p>3) Emergency treatment of status epilepticus.<sup class="text-reference-group"><a class="reference-popover-link" data-content="Prasad M, Krishnan PR, Sequeira R, Al-Roomi K: Anticonvulsant therapy for status epilepticus. Cochrane Database Syst Rev. 2014 Sep 10;(9):CD003723. doi: 10.1002/14651858.CD003723.pub3. (PubMed ID 25207925)" href="#reference-A177955">11</a></sup></p>