<p>Losartan is approximately 33% orally bioavailable.<sup class="text-reference-group"><a class="reference-popover-link" data-content="Sica DA, Gehr TW, Ghosh S: Clinical pharmacokinetics of losartan. Clin Pharmacokinet. 2005;44(8):797-814. (PubMed ID 16029066)" href="#reference-A1033">1</a>,<a class="reference-popover-link" data-content="FDA Approved Drug Products: Losartan Oral Tablets" href="#reference-L7423">3</a>,<a class="reference-popover-link" data-content="FDA Approved Drug Products: Losartan and Hydrochlorothiazide Oral Tablets" href="#reference-L7426">4</a></sup> Losartan has a T<sub>max</sub> of 1 hour and the active metabolite has a T<sub>max</sub> of 3-4 hours.<sup class="text-reference-group"><a class="reference-popover-link" data-content="Sica DA, Gehr TW, Ghosh S: Clinical pharmacokinetics of losartan. Clin Pharmacokinet. 2005;44(8):797-814. (PubMed ID 16029066)" href="#reference-A1033">1</a>,<a class="reference-popover-link" data-content="FDA Approved Drug Products: Losartan Oral Tablets" href="#reference-L7423">3</a>,<a class="reference-popover-link" data-content="FDA Approved Drug Products: Losartan and Hydrochlorothiazide Oral Tablets" href="#reference-L7426">4</a></sup> Taking losartan with food decreases the C<sub>max</sub> but does only results in a 10% decrease in the AUC of losartan and its active metabolite.<sup class="text-reference-group"><a class="reference-popover-link" data-content="Sica DA, Gehr TW, Ghosh S: Clinical pharmacokinetics of losartan. Clin Pharmacokinet. 2005;44(8):797-814. (PubMed ID 16029066)" href="#reference-A1033">1</a>,<a class="reference-popover-link" data-content="FDA Approved Drug Products: Losartan Oral Tablets" href="#reference-L7423">3</a>,<a class="reference-popover-link" data-content="FDA Approved Drug Products: Losartan and Hydrochlorothiazide Oral Tablets" href="#reference-L7426">4</a></sup> A 50-80mg oral dose of losartan leads to a C<sub>max</sub> of 200-250ng/mL.<sup class="text-reference-group"><a class="reference-popover-link" data-content="Sica DA, Gehr TW, Ghosh S: Clinical pharmacokinetics of losartan. Clin Pharmacokinet. 2005;44(8):797-814. (PubMed ID 16029066)" href="#reference-A1033">1</a></sup></p>