<p>Sublingual dosing leads to a C<sub>max</sub> of 10ng/mL, with a T<sub>max</sub> of 50min, and an AUC of 25ng*h/mL.<sup class="text-reference-group"><a class="reference-popover-link" data-content="van Harten J, Burggraaf K, Danhof M, van Brummelen P, Breimer DD: Negligible sublingual absorption of nifedipine. Lancet. 1987 Dec 12;2(8572):1363-5. doi: 10.1016/s0140-6736(87)91258-x. (PubMed ID 2890954)" href="#reference-A190264">9</a></sup> Oral dosing leads to a C<sub>max</sub> of 82ng/mL, with a T<sub>max</sub> of 28min, and an AUC of 152ng*h/mL.<sup class="text-reference-group"><a class="reference-popover-link" data-content="van Harten J, Burggraaf K, Danhof M, van Brummelen P, Breimer DD: Negligible sublingual absorption of nifedipine. Lancet. 1987 Dec 12;2(8572):1363-5. doi: 10.1016/s0140-6736(87)91258-x. (PubMed ID 2890954)" href="#reference-A190264">9</a></sup></p><p>Nifedipine is a Biopharmaceutics Classification System Class II drug, meaning it has low solubility and high intestinal permeability.<sup class="text-reference-group"><a class="reference-popover-link" data-content="Nader AM, Quinney SK, Fadda HM, Foster DR: Effect of Gastric Fluid Volume on the In Vitro Dissolution and In Vivo Absorption of BCS Class II Drugs: a Case Study with Nifedipine. AAPS J. 2016 Jul;18(4):981-8. doi: 10.1208/s12248-016-9918-x. Epub 2016 Apr 22. (PubMed ID 27106837)" href="#reference-A190261">8</a></sup> It is almost completely absorbed in the gastrointestinal tract but has a bioavilability of 45-68%, partly due to first pass metabolism.<sup class="text-reference-group"><a class="reference-popover-link" data-content="Chung M, Reitberg DP, Gaffney M, Singleton W: Clinical pharmacokinetics of nifedipine gastrointestinal therapeutic system. A controlled-release formulation of nifedipine. Am J Med. 1987 Dec 21;83(6B):10-4. doi: 10.1016/0002-9343(87)90630-9. (PubMed ID 3503594)" href="#reference-A190210">3</a>,<a class="reference-popover-link" data-content="Nader AM, Quinney SK, Fadda HM, Foster DR: Effect of Gastric Fluid Volume on the In Vitro Dissolution and In Vivo Absorption of BCS Class II Drugs: a Case Study with Nifedipine. AAPS J. 2016 Jul;18(4):981-8. doi: 10.1208/s12248-016-9918-x. Epub 2016 Apr 22. (PubMed ID 27106837)" href="#reference-A190261">8</a></sup></p>