The agriculture sector is facing significant challenges due to climate change in many regions of the world, including Sub-Saharan Africa, which impacts food production, nutrition, and food security. A study conducted on 32 Sub-Saharan African countries between 2005 and 2019 using Fixed Effects (FE) and Two-Step System-Generalized Method of Moments (GMM) estimation shows the effect of climate change on agriculture production. Adapting to climate change is becoming riskier for agriculture production and agro-ecosystems. The agriculture sector needs to strive for a low carbon economy to prevent further depletion of agricultural grounds. Population growth and control measures, socio-economic challenges, and government policies are also affecting agricultural production. Organizations and governments need to take action to combat these negative impacts and build resilience in the food system. Mitigating new risks is of utmost importance to revitalize the agricultural fields.