<p>Tamoxifen is mainly eliminated in the feces.<sup class="text-reference-group"><a class="reference-popover-link" data-content="FDA Approved Drug Products: Tamoxifen Oral Tablets" href="#reference-L7799">15</a>,<a class="reference-popover-link" data-content="FDA Approved Drug Products: Tamoxifen Oral Solution" href="#reference-L7802">16</a></sup> Animal studies have shown 75% of radiolabelled tamoxifen recovered in the feces, with negligible collection from urine.<sup class="text-reference-group"><a class="reference-popover-link" data-content="Fromson JM, Pearson S, Bramah S: The metabolism of tamoxifen (I.C.I. 46,474). I. In laboratory animals. Xenobiotica. 1973 Nov;3(11):693-709. doi: 10.3109/00498257309151594. (PubMed ID 4361333)" href="#reference-A182201">9</a></sup> However, 1 human study showed 26.7% recovery in the urine and 24.7% in the feces.<sup class="text-reference-group"><a class="reference-popover-link" data-content="Kisanga ER, Mellgren G, Lien EA: Excretion of hydroxylated metabolites of tamoxifen in human bile and urine. Anticancer Res. 2005 Nov-Dec;25(6C):4487-92. (PubMed ID 16334131)" href="#reference-A182204">10</a></sup></p>