<p>Following a single intravenous injection in healthy male volunteers, the systemic clearance of diltiazem was approximately 65 L/h. After constant rate intravenous infusion, the systemic clearance decreased to 48 L/h.<sup class="text-reference-group"><a class="reference-popover-link" data-content="Diltiazem Hydrochloride Injection Label - Bedford Laboratories" href="#reference-L6292">10</a></sup></p>