<p>The LD<sub>50</sub> is 0.78µg/mL in males and 0.98µg/mL in females.<sup class="text-reference-group"><a class="reference-popover-link" data-content="Shigeev S: Severity of opiate intoxication to gender and age. Soud Lek. 2007 Jan;52(1):21-4. (PubMed ID 17370507)" href="#reference-A176167">9</a></sup></p><p>Patients experiencing an overdose present with respiratory depression, somnolence, skeletal muscle flaccidity, cold and clammy skin, miosis, and mydriasis. Symptoms of overdose can progress to pulmonary edema, bradycardia, hypotension, cardiac arrest, and death.<sup class="text-reference-group"><a class="reference-popover-link" data-content="FDA Approved Drug Products: Infumorph Morphine Sulfate Injection" href="#reference-L12108">12</a></sup> Treat overdose with symptomatic and supportive treatment which may include the use of oxygen, vasopressors, and naloxone.<sup class="text-reference-group"><a class="reference-popover-link" data-content="FDA Approved Drug Products: Infumorph Morphine Sulfate Injection" href="#reference-L12108">12</a></sup></p>