<p>Total hydrocortisone via the oral route has a half life of 2.15h while the free fraction has a half life of 1.39h.<sup class="text-reference-group"><a class="reference-popover-link" data-content="Werumeus Buning J, Touw DJ, Brummelman P, Dullaart RPF, van den Berg G, van der Klauw MM, Kamp J, Wolffenbuttel BHR, van Beek AP: Pharmacokinetics of oral hydrocortisone - Results and implications from a randomized controlled trial. Metabolism. 2017 Jun;71:7-16. doi: 10.1016/j.metabol.2017.02.005. Epub 2017 Feb 13. (PubMed ID 28521880)" href="#reference-A188354">1</a></sup> A 20mg IV dose of hydrocortisone has a terminal half life of 1.9±0.4h.<sup class="text-reference-group"><a class="reference-popover-link" data-content="Derendorf H, Mollmann H, Barth J, Mollmann C, Tunn S, Krieg M: Pharmacokinetics and oral bioavailability of hydrocortisone. J Clin Pharmacol. 1991 May;31(5):473-6. doi: 10.1002/j.1552-4604.1991.tb01906.x. (PubMed ID 2050835)" href="#reference-A188381">6</a></sup></p>