<p>Losartan is metabolized to an aldehyde intermediate, E-3179, which is further metabolized to a carboxylic acid, E-3174, by cytochrome P450s like CYP2C9.<sup class="text-reference-group"><a class="reference-popover-link" data-content="Sica DA, Gehr TW, Ghosh S: Clinical pharmacokinetics of losartan. Clin Pharmacokinet. 2005;44(8):797-814. (PubMed ID 16029066)" href="#reference-A1033">1</a></sup> Losartan can also be hydroxylated to an inactive metabolite, P1.<sup class="text-reference-group"><a class="reference-popover-link" data-content="Sica DA, Gehr TW, Ghosh S: Clinical pharmacokinetics of losartan. Clin Pharmacokinet. 2005;44(8):797-814. (PubMed ID 16029066)" href="#reference-A1033">1</a></sup> Approximately 14% of losartan is metabolized to E-3174.<sup class="text-reference-group"><a class="reference-popover-link" data-content="Sica DA, Gehr TW, Ghosh S: Clinical pharmacokinetics of losartan. Clin Pharmacokinet. 2005;44(8):797-814. (PubMed ID 16029066)" href="#reference-A1033">1</a></sup> Losartan can be metabolized by CYP3A4, CYP2C9, and CYP2C10.<sup class="text-reference-group"><a class="reference-popover-link" data-content="Sica DA, Gehr TW, Ghosh S: Clinical pharmacokinetics of losartan. Clin Pharmacokinet. 2005;44(8):797-814. (PubMed ID 16029066)" href="#reference-A1033">1</a></sup> Losartan can also be glucuronidated by UGT1A1, UGT1A3, UGT1A10, UGT2B7, and UGT 2B17.<sup class="text-reference-group"><a class="reference-popover-link" data-content="Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. (PubMed ID 19515014)" href="#reference-A415">2</a></sup></p><p class="d-none d-sm-block"><strong>Hover over products below to view reaction partners</strong></p>