<p>The volume of distribution of meloxicam is 10-15L. Because of its high binding to albumin, it is likely to be distributed in highly perfused tissues, such as the liver and kidney.<sup class="text-reference-group"><a class="reference-popover-link" data-content="Bekker A, Kloepping C, Collingwood S: Meloxicam in the management of post-operative pain: Narrative review. J Anaesthesiol Clin Pharmacol. 2018 Oct-Dec;34(4):450-457. doi: 10.4103/joacp.JOACP_133_18. (PubMed ID 30774225)" href="#reference-A190189">1</a></sup> Meloxicam concentrations in synovial fluid, measured after an oral dose, is estimated at 40% to 50% of the concentrations measured in the plasma.<sup class="text-reference-group"><a class="reference-popover-link" data-content="FDA approved products: Mobic (meloxicam) oral tablets" href="#reference-L11398">10</a></sup> This drug is known to cross the placenta in humans.<sup class="text-reference-group"><a class="reference-popover-link" data-content="Carl P. Weiner MD, MBA, FACOG, Clifford Mason PhD (2019). Drugs for Pregnant and Lactating Women (3rd ed.). Elsevier." href="#reference-T757">9</a></sup></p>