<p>Erythromycin is found in most body fluids and accumulates in leucocytes and inflammatory liquid.<sup class="text-reference-group"><a class="reference-popover-link" data-content="FDA Approved Drug Products: Ery-Ped (erythromycin ethylsuccinate) granules for oral suspension" href="#reference-L7261">21</a>,<a class="reference-popover-link" data-content="Krasniqi S, Matzneller P, Kinzig M, Sorgel F, Huttner S, Lackner E, Muller M, Zeitlinger M: Blood, tissue, and intracellular concentrations of erythromycin and its metabolite anhydroerythromycin during and after therapy. Antimicrob Agents Chemother. 2012 Feb;56(2):1059-64. doi: 10.1128/AAC.05490-11. Epub 2011 Nov 14. (PubMed ID 22083477)" href="#reference-A174448">5</a>,<a class="reference-popover-link" data-content="Kavi J, Webberley JM, Andrews JM, Wise R: A comparison of the pharmacokinetics and tissue penetration of spiramycin and erythromycin. J Antimicrob Chemother. 1988 Jul;22 Suppl B:105-10. doi: 10.1093/jac/22.supplement_b.105. (PubMed ID 3182434)" href="#reference-A180607">19</a></sup> Spinal fluid concentrations of erythromycin are low, however, the diffusion of erythromycin through the blood-brain barrier increases in meningitis, likely due to the presence of inflamed tissues which are easily penetrated.<sup class="text-reference-group"><a class="reference-popover-link" data-content="MedSafe NZ: ERA (erythromycin stearate) oral filmtabs" href="#reference-L7270">22</a></sup> Erythromycin crosses the placenta.<sup class="text-reference-group"><a class="reference-popover-link" data-content="FDA Approved Drug Products: Ery-Ped (erythromycin ethylsuccinate) granules for oral suspension" href="#reference-L7261">21</a></sup></p>