<p>Imipramine has a mean clearance of 1 L/h/kg. Its active metabolite, desipramine has a mean clearance of 1.8 L/h/kg <sup class="text-reference-group"><a class="reference-popover-link" data-content="Sallee FR, Pollock BG: Clinical pharmacokinetics of imipramine and desipramine. Clin Pharmacokinet. 1990 May;18(5):346-64. (PubMed ID 2185906)" href="#reference-A31907">3</a></sup>.</p>