<p>Progesterone is mainly metabolized by the liver. After oral administration, the major plasma metabolites found are 20 a hydroxy-Δ4 a-prenolone and 5 a-dihydroprogesterone. Some progesterone metabolites are found excreted in the bile and these metabolites may be deconjugated and subsequently metabolized in the gut by reduction, dehydroxylation, and epimerization <sup class="text-reference-group"><a class="reference-popover-link" data-content="Official drug label" href="#label-reference">Label</a></sup>. The major plasma and urinary metabolites are comparable to those found during the physiological progesterone secretion of the corpus luteum <sup class="text-reference-group"><a class="reference-popover-link" data-content="Utrogestan capsules, medsafe NZ label" href="#reference-F3913">24</a></sup>. </p><p class="d-none d-sm-block"><strong>Hover over products below to view reaction partners</strong></p>