<p>This drug is metabolized to the main metabolite desethylamiodarone (DEA)<sup class="text-reference-group"><a class="reference-popover-link" data-content="Latini R, Tognoni G, Kates RE: Clinical pharmacokinetics of amiodarone. Clin Pharmacokinet. 1984 Mar-Apr;9(2):136-56. doi: 10.2165/00003088-198409020-00002. (PubMed ID 6370540)" href="#reference-A36817">4</a></sup> by the CYP3A4 and CYP2C8 enzymes. The CYP3A4 enzyme is found in the liver and intestines.<sup class="text-reference-group"><a class="reference-popover-link" data-content="FDA Approved Drug Products: CORDARONE (amiodarone HCl) tablets" href="#reference-L3561">18</a></sup> A hydroxyl metabolite of DEA has been identified in mammals, but its clinical significance is unknown.<sup class="text-reference-group"><a class="reference-popover-link" data-content="Ha HR, Bigler L, Binder M, Kozlik P, Stieger B, Hesse M, Altorfer HR, Follath F: Metabolism of amiodarone (part I): identification of a new hydroxylated metabolite of amiodarone. Drug Metab Dispos. 2001 Feb;29(2):152-8. (PubMed ID 11159805)" href="#reference-A189829">12</a></sup></p><p class="d-none d-sm-block"><strong>Hover over products below to view reaction partners</strong></p>