<p>Thus cytochrome P450 metabolism, glucuronide conjugation, and urinary excretion of glucuronidated metabolites represent the primary route of nevirapine biotransformation and elimination in humans. Only a small fraction (&lt;5%) of the radioactivity in urine (representing &lt;3% of the total dose) was made up of parent compound; therefore, renal excretion plays a minor role in elimination of the parent compound.</p>