<p>Acute oral LD50 is 2.42 mg/kg in rats and 13 mg/kg in mice.<sup class="text-reference-group"><a class="reference-popover-link" data-content="Material Safety Data Sheet" href="#msds-reference">MSDS</a></sup> The oral LD50 of indomethacin in mice and rats (based on 14-day mortality response) was 50 and 12 mg/kg, respectively.<sup class="text-reference-group"><a class="reference-popover-link" data-content="Indomethacin Capsules (25 mg) - FDA Label" href="#reference-L6778">13</a></sup> </p><p>Symptoms of overdose may be characterized by nausea, vomiting, intense headache, dizziness, mental confusion, disorientation, or lethargy. In addition, there have been reports of paresthesias, numbness, and convulsions. In case of an overdose, the patient should receive symptomatic and supportive treatment with stomach emptying through induced vomiting or gastric lavage.<sup class="text-reference-group"><a class="reference-popover-link" data-content="Indomethacin Capsules (25 mg) - FDA Label" href="#reference-L6778">13</a></sup> The patient should then be closely monitored for any signs of gastrointestinal ulceration and hemorrhage. Antacids may be useful.<sup class="text-reference-group"><a class="reference-popover-link" data-content="Indomethacin Capsules (25 mg) - FDA Label" href="#reference-L6778">13</a></sup></p>