<li>Avoid excessive or chronic alcohol consumption.</li>
<li>Avoid grapefruit products. Grapefruit down-regulates post-translational expression of CYP3A4, the major metabolizing enzyme of nifedipine. Grapefruit, in all forms (e.g. whole fruit, juice and rind), can significantly increase serum levels of nifedipine and may cause toxicity. Avoid grapefruit products while on this medication.</li>
<li>Avoid natural licorice.</li>
<li>Take with or without food.</li>