<p>Nifedipine is predominantly metabolized by CYP3A4.<sup class="text-reference-group"><a class="reference-popover-link" data-content="Khan KM, Patel J, Schaefer TJ: Nifedipine . (PubMed ID 30725737)" href="#reference-A190204">1</a>,<a class="reference-popover-link" data-content="Nader AM, Quinney SK, Fadda HM, Foster DR: Effect of Gastric Fluid Volume on the In Vitro Dissolution and In Vivo Absorption of BCS Class II Drugs: a Case Study with Nifedipine. AAPS J. 2016 Jul;18(4):981-8. doi: 10.1208/s12248-016-9918-x. Epub 2016 Apr 22. (PubMed ID 27106837)" href="#reference-A190261">8</a>,<a class="reference-popover-link" data-content="FDA Approved Drug Products: Procardia Nifedipine Oral Capsules" href="#reference-L11383">13</a>,<a class="reference-popover-link" data-content="FDA Approved Drug Products: Procardia XL Nifedipine Oral Extended Release Tablets" href="#reference-L11389">14</a>,<a class="reference-popover-link" data-content="FDA Approved Drug Products: Adalat CC Nifedipine Oral Extended Release Tablets" href="#reference-L1245">15</a></sup> Nifedipine is predominantly metabolized to 2,6-dimethyl-4-(2-nitrophenyl)-5-methoxycarbonyl-pyridine-3-carboxylic acid, and then further metabolized to 2-hydroxymethyl-pyridine carboxylic acid.<sup class="text-reference-group"><a class="reference-popover-link" data-content="Raemsch KD, Sommer J: Pharmacokinetics and metabolism of nifedipine. Hypertension. 1983 Jul-Aug;5(4 Pt 2):II18-24. doi: 10.1161/01.hyp.5.4_pt_2.ii18. (PubMed ID 6862586)" href="#reference-A190228">6</a></sup> Nifedipine is also minorly metabolized to dehydronifedipine.<sup class="text-reference-group"><a class="reference-popover-link" data-content="Waller DG, Renwick AG, Gruchy BS, George CF: The first pass metabolism of nifedipine in man. Br J Clin Pharmacol. 1984 Dec;18(6):951-4. doi: 10.1111/j.1365-2125.1984.tb02569.x. (PubMed ID 6529535)" href="#reference-A190225">7</a></sup></p><p class="d-none d-sm-block"><strong>Hover over products below to view reaction partners</strong></p>