<p><strong>Oral</strong></p><p>Indicated for the management of hypertension, to lower blood pressure, alone or in combination with other antihypertensive agents.<sup class="text-reference-group"><a class="reference-popover-link" data-content="CARDIZEM® LA (diltiazem hydrochloride) extended-release tablets - FDA Label" href="#reference-L10556">12</a></sup></p><p>Indicated for use to improve exercise tolerance in patients with chronic stable angina.<sup class="text-reference-group"><a class="reference-popover-link" data-content="CARDIZEM® LA (diltiazem hydrochloride) extended-release tablets - FDA Label" href="#reference-L10556">12</a></sup></p><p>Indicated for the management of variant angina (Prinzmetal's angina).<sup class="text-reference-group"><a class="reference-popover-link" data-content="Cardizem (diltiazem hydrochloride) Drug Summary - PDR.net" href="#reference-L6298">11</a></sup></p><p><strong>Intravenous</strong></p><p>Indicated for the short-term management of atrial fibrillation or atrial flutter for temporary control of rapid ventricular rate.<sup class="text-reference-group"><a class="reference-popover-link" data-content="Diltiazem Hydrochloride Injection Label - Bedford Laboratories" href="#reference-L6292">10</a></sup></p><p>Indicated for the rapid conversion of paroxysmal supraventricular tachycardias (PSVT) to sinus rhythm. This includes AV nodal reentrant tachycardias and reciprocating tachycardias associated with an extranodal accessory pathway such as the WPW syndrome or short PR syndrome.<sup class="text-reference-group"><a class="reference-popover-link" data-content="Diltiazem Hydrochloride Injection Label - Bedford Laboratories" href="#reference-L6292">10</a></sup></p><p><strong>Off-label</strong></p><p>Indicated for off-label uses in anal fissures (as topical formulation), migraine prophylaxis, cramps in lower leg related to rest, pulmonary hypertension,<sup class="text-reference-group"><a class="reference-popover-link" data-content="Diltiazem - StatPearls - NCBI Bookshelf" href="#reference-L6289">9</a></sup> idiopathic dilated cardiomyopathy, and proteinuria associated with diabetic nephropathy.<sup class="text-reference-group"><a class="reference-popover-link" data-content="Cardizem (diltiazem hydrochloride) Drug Summary - PDR.net" href="#reference-L6298">11</a></sup></p>