<p>Acetylsalicylic acid is hydrolyzed in the plasma to salicylic acid. Plasma concentrations of aspirin following after administration of the extended-release form are mostly undetectable 4-8 hours after ingestion of a single dose. Salicylic acid was measured at 24 hours following a single dose of extended-release acetylsalicylic acid <sup class="text-reference-group"><a class="reference-popover-link" data-content="Durlaza FDA label" href="#reference-F4405">21</a></sup>.</p><p>Salicylate is mainly metabolized in the liver, although other tissues may also be involved in this process <sup class="text-reference-group"><a class="reference-popover-link" data-content="Official drug label" href="#label-reference">Label</a></sup>. The major metabolites of acetylsalicylic acid are salicylic acid, salicyluric acid, the ether or phenolic glucuronide and the ester or acyl glucuronide. A small portion is converted to gentisic acid and other hydroxybenzoic acids <sup class="text-reference-group"><a class="reference-popover-link" data-content="Official drug label" href="#label-reference">Label</a></sup>.</p><p class="d-none d-sm-block"><strong>Hover over products below to view reaction partners</strong></p>