Scientists explore biodegradable plasticizers as eco-friendly alternatives to traditional ones, but developing efficient and cost-effective manufacturing methods poses challenges. Natural-based plasticizers, like glycerol, zein, and soy protein isolate, are being explored for biodegradable films. New polymer blends, including PHA and PHB, have been developed for faster degradation. Despite challenges, demand for eco-friendly options has risen, making it important to find sustainable alternatives to traditional plastics.