<p>Although the over-the-counter (OTC) availability of naproxen provides convenience to patients, it also increases the likelihood of overdose.<sup class="text-reference-group"><a class="reference-popover-link" data-content="Brutzkus JC, Varacallo M: Naproxen . (PubMed ID 30247840)" href="#reference-A178975">3</a></sup> Thankfully, the extent of overdose is typically mild with adverse effects normally limited to drowsiness, lethargy, epigastric pain, nausea and vomiting.<sup class="text-reference-group"><a class="reference-popover-link" data-content="Brutzkus JC, Varacallo M: Naproxen . (PubMed ID 30247840)" href="#reference-A178975">3</a></sup><sup class="text-reference-group"><a class="reference-popover-link" data-content="Naprelan FDA Label" href="#reference-L6582">12</a></sup><sup class="text-reference-group"><a class="reference-popover-link" data-content="Naprosyn FDA Label" href="#reference-L6583">13</a></sup> Although there is no antidote for naproxen overdose, symptoms will typically subside with appropriate supportive care.<sup class="text-reference-group"><a class="reference-popover-link" data-content="Naprelan FDA Label" href="#reference-L6582">12</a></sup><sup class="text-reference-group"><a class="reference-popover-link" data-content="Naprosyn FDA Label" href="#reference-L6583">13</a></sup><sup class="text-reference-group"><a class="reference-popover-link" data-content="Brutzkus JC, Varacallo M: Naproxen . (PubMed ID 30247840)" href="#reference-A178975">3</a></sup></p><p>Naproxen is classified as Category B during the first 2 trimesters of pregnancy, and as Category D during the third trimester.<sup class="text-reference-group"><a class="reference-popover-link" data-content="Over-the-counter Medications in Pregnancy" href="#reference-L6595">14</a></sup> Naproxen is contraindicated in the 3rd trimester since it increases the risk of premature closure of the fetal ductus arteriosus and should be avoided in pregnant women starting at 30 weeks gestation.<sup class="text-reference-group"><a class="reference-popover-link" data-content="Naprelan FDA Label" href="#reference-L6582">12</a></sup><sup class="text-reference-group"><a class="reference-popover-link" data-content="Naprosyn FDA Label" href="#reference-L6583">13</a></sup></p>