<p>Minocycline was first described in the literacture in 1966.<sup class="text-reference-group"><a class="reference-popover-link" data-content="Redin GS: Antibacterial activity in mice of minocycline, a new tetracycline. Antimicrob Agents Chemother (Bethesda). 1966;6:371-6. (PubMed ID 5985260)" href="#reference-A190681">1</a></sup> It is a second generation tetracycline antibiotic that is active against gram-negative and gram-positive bacteria.<sup class="text-reference-group"><a class="reference-popover-link" data-content="Garrido-Mesa N, Zarzuelo A, Galvez J: Minocycline: far beyond an antibiotic. Br J Pharmacol. 2013 May;169(2):337-52. doi: 10.1111/bph.12139. (PubMed ID 23441623)" href="#reference-A190723">7</a></sup> Like other semisynthetic tetracyclines, minocycline has modifications to carbons 7-9 on the D ring to generate higher efficacy than previous tetracyclines.<sup class="text-reference-group"><a class="reference-popover-link" data-content="Garrido-Mesa N, Zarzuelo A, Galvez J: Minocycline: far beyond an antibiotic. Br J Pharmacol. 2013 May;169(2):337-52. doi: 10.1111/bph.12139. (PubMed ID 23441623)" href="#reference-A190723">7</a></sup></p><p>Minocycline was granted FDA approval on 30 June 1971.<sup class="text-reference-group"><a class="reference-popover-link" data-content="FDA Approved Drug Products: Minocin Minocycline Oral Capsules (Discontinued)" href="#reference-L11695">9</a></sup></p>