<p>Clinical consequences from overdose depend on the extent of electrolyte and fluid loss and include dehydration, blood volume reduction, hypotension, electrolyte imbalance, hypokalemia, hypochloremic alkalosis,<sup class="text-reference-group"><a class="reference-popover-link" data-content="Furosemide - FDA Label" href="#reference-L7958">9</a></sup> hemoconcentration, cardiac arrhythmias (including A-V block and ventricular fibrillation).<sup class="text-reference-group"><a class="reference-popover-link" data-content="Lasix Oral (furosemide) Product Monograph" href="#reference-L9659">12</a></sup> Symptoms of overdose include acute renal failure, thrombosis, delirious states, flaccid paralysis, apathy and confusion. In cirrhotic patients, overdosage might precipitate hepatic coma.<sup class="text-reference-group"><a class="reference-popover-link" data-content="Lasix Oral (furosemide) Product Monograph" href="#reference-L9659">12</a></sup></p><p>In rats, the oral LD<sub>50</sub>, intraperitoneal LD<sub>50</sub>, and subcutaneous LD<sub>50</sub> is 2600 mg/kg, 800 mg/kg, and 4600 mg/kg, respectively. The Lowest published toxic dose (TDLo) in a female is 6250 μg/kg.<sup class="text-reference-group"><a class="reference-popover-link" data-content="Furosemide SAFETY DATA SHEET - Cayman Chemical" href="#reference-L7964">11</a></sup></p>