<p>Doxycycline is indicated for the treatment of various infections by gram-positive and gram-negative bacteria, aerobes and anaerobes, as well other types of bacteria. A complete list of organisms is available in the FDA label and in the "indications" section of this drug entry <sup class="text-reference-group"><a class="reference-popover-link" data-content="Official drug label" href="#label-reference">Label</a></sup>.</p><p>The following are some of the major infections that may be treated with doxycycline <sup class="text-reference-group"><a class="reference-popover-link" data-content="Official drug label" href="#label-reference">Label</a></sup>:</p><p>Rocky mountain spotted fever, typhus fever and the typhus group, Q fever, rickettsialpox, and tick fevers caused by Rickettsiae</p><p>Respiratory tract infections caused by Mycoplasma pneumoniae</p><p>Lymphogranuloma venereum caused by Chlamydia trachomatis</p><p>Psittacosis (ornithosis) caused by Chlamydia psittaci</p><p>Trachoma caused by Chlamydia trachomatis, although the infectious agent is not always eliminated as judged by immunofluorescence</p><p>Inclusion conjunctivitis caused by Chlamydia trachomatis</p><p>Uncomplicated urethral, endocervical or rectal infections in adults caused by Chlamydia trachomatis</p><p>Nongonococcal urethritis caused by Ureaplasma urealyticum</p><p>Relapsing fever due to Borrelia recurrentis</p><p><strong>A note regarding anti-microbial resistance</strong></p><p>It is important to note that doxycycline is not the drug of choice in the treatment of any type of staphylococcal infection.
Up to 44 percent of strains of Streptococcus pyogenes and 74 percent of Streptococcus faecalis have been found to be resistant to tetracyclines. Therefore, tetracyclines such as doxycycline should not be used to treat streptococcal infections unless the microorganism has been demonstrated to be susceptible <sup class="text-reference-group"><a class="reference-popover-link" data-content="Official drug label" href="#label-reference">Label</a></sup>.</p>