<p>The half-life from the dose of 40 mg furosemide was 4 hours following oral administration and 4.5 hours following intravenous administration. The terminal half-life of furosemide is approximately 2 hours following parenteral administration.<sup class="text-reference-group"><a class="reference-popover-link" data-content="Furosemide - FDA Label" href="#reference-L7958">9</a></sup> The terminal half-life may be increased up to 24 hours in patients with severe renal failure.<sup class="text-reference-group"><a class="reference-popover-link" data-content="Lasix Oral (furosemide) Product Monograph" href="#reference-L9659">12</a></sup></p>