<p>The oral LD<sub>50</sub> in rats is 1022mg/kg and in mice is 202mg/kg.<sup class="text-reference-group"><a class="reference-popover-link" data-content="Cayman Chemical: Nifedipine MSDS" href="#reference-L11428">16</a></sup></p><p>Patients experiencing an overdose may present with hypotension, sinus node dysfunction, atrioventricular node dysfunction, and reflex tachycardia.<sup class="text-reference-group"><a class="reference-popover-link" data-content="Herrington DM, Insley BM, Weinmann GG: Nifedipine overdose. Am J Med. 1986 Aug;81(2):344-6. doi: 10.1016/0002-9343(86)90276-7. (PubMed ID 3740090)" href="#reference-A190219">4</a>,<a class="reference-popover-link" data-content="Whitebloom D, Fitzharris J: Nifedipine overdose. Clin Cardiol. 1988 Jul;11(7):505-6. doi: 10.1002/clc.4960110714. (PubMed ID 3416517)" href="#reference-A190222">5</a></sup> Overdose may be managed by monitoring cardiovascular and respiratory function; elevating extremities; and administering vasopressors, fluids, and calcium infusions.<sup class="text-reference-group"><a class="reference-popover-link" data-content="FDA Approved Drug Products: Procardia Nifedipine Oral Capsules" href="#reference-L11383">13</a></sup></p>