<p>The effective half-life of celecoxib is approximately 11 hours when a single 200 mg dose is given to healthy subjects.<sup class="text-reference-group"><a class="reference-popover-link" data-content="Pfizer Medical Information" href="#reference-L3296">25</a>,<a class="reference-popover-link" data-content="FDA Approved Drug Products: CELEBREX (celecoxib) oral capsules" href="#reference-L7646">31</a></sup> The terminal half-life of celecoxib varies because of its low solubility, which prolongs absorption.<sup class="text-reference-group"><a class="reference-popover-link" data-content="FDA Approved Drug Products: CELEBREX (celecoxib) oral capsules" href="#reference-L7646">31</a></sup></p>