<p>In clinical trials, over 10% of patients experienced back pain, arthralgia, abdominal pain, and dyspepsia<sup class="text-reference-group"><a class="reference-popover-link" data-content="Official drug label" href="#label-reference">Label</a></sup>. Less commonly, patients experience angioedema, generalized rash, bullous skin reactions, iritis, and uveitis<sup class="text-reference-group"><a class="reference-popover-link" data-content="Official drug label" href="#label-reference">Label</a></sup>.</p><p>Patients experiencing an overdose may experience a decrease in serum calcium and phosphorus<sup class="text-reference-group"><a class="reference-popover-link" data-content="Official drug label" href="#label-reference">Label</a></sup>. Patients can be given milk or antacids to bind the drug and reduce its absorption<sup class="text-reference-group"><a class="reference-popover-link" data-content="Official drug label" href="#label-reference">Label</a></sup>. In more severe cases, patients may require gastric lavage and intravenous calcium<sup class="text-reference-group"><a class="reference-popover-link" data-content="Official drug label" href="#label-reference">Label</a></sup>. A lethal dose in rats is equivalent to 320 to 620 times the human dose based on surface area<sup class="text-reference-group"><a class="reference-popover-link" data-content="Official drug label" href="#label-reference">Label</a></sup>.</p>