<p>The clearance rate of acetylsalicylic acid is extremely variable, depending on several factors <sup class="text-reference-group"><a class="reference-popover-link" data-content="Levy G: Clinical pharmacokinetics of aspirin. Pediatrics. 1978 Nov;62(5 Pt 2 Suppl):867-72. (PubMed ID 724339)" href="#reference-A177217">6</a></sup>. Dosage adjustments may be required in patients with renal impairment <sup class="text-reference-group"><a class="reference-popover-link" data-content="Official drug label" href="#label-reference">Label</a></sup>. The extended-release tablet should not be administered to patients with eGFR of less than 10 mL/min <sup class="text-reference-group"><a class="reference-popover-link" data-content="Durlaza FDA label" href="#reference-F4405">21</a></sup>.</p>