<p>Metabolites of spironolactone are excreted 42-56% in urine, and 14.2-14.6% in the feces.<sup class="text-reference-group"><a class="reference-popover-link" data-content="Karim A: Spironolactone: disposition, metabolism, pharmacodynamics, and bioavailability. Drug Metab Rev. 1978;8(1):151-88. doi: 10.3109/03602537808993782. (PubMed ID 363379)" href="#reference-A178165">6</a></sup> No unmetabolized spironolactone is present in the urine.<sup class="text-reference-group"><a class="reference-popover-link" data-content="Karim A: Spironolactone: disposition, metabolism, pharmacodynamics, and bioavailability. Drug Metab Rev. 1978;8(1):151-88. doi: 10.3109/03602537808993782. (PubMed ID 363379)" href="#reference-A178165">6</a></sup></p>